Furthermore, the results show that α-hEGFR-IL achieved favorable cellular tumor binding in an intracranial xenograft model. This endorses α-hEGFR-IL as a good candidate for
targeted drug delivery purposes in targeted therapeutic approaches for treatment for GBM in future clinical studies. Acknowledgments The data in this study were generated by generous support from Eva og Henry Frænkels Mindefond, Familien Erichsens Mindefond, speciallæge Heinrich Kopps Legat, and the Obelske Family Fund. Abbreviations α-hEGFR: Anti-human epidermal growth factor receptor antibodies CNS: Central nervous system DAPI: 4′,6-diamidino-2-phenylindole Inhibitors,research,lifescience,medical EGFR: Epidermal growth factor receptor EPR: Enhanced penetration and retention GBM: Glioblastoma multiforme IL: Immunoliposome.
A suspension is a dispersed system in which the internal phase consists of solid particles and the external phase is a liquid Inhibitors,research,lifescience,medical vehicle. Suspensions are the best conventional liquid dosage forms of drugs with high bioavailability in comparison to other dosage forms except solutions, and they have patient compliance [1, 2]. Rheological study of suspensions provides valuable information for efficient utilization, Selleck INK 128 transport, and handling of materials in industrial applications
. The thixotropy and hysteresis loop Inhibitors,research,lifescience,medical are rheological phenomena. In non-Newtonian systems if the rate of shear was reduced once the desired maximum rate had been reached, the down curve can be displaced relative to the up curve. With pseudoplastic systems, the down curve is frequently displaced to the left of the up curve. This phenomenon, known as thixotropy, can be defined as an isothermal and comparatively slow recovery, on standing of a material, Inhibitors,research,lifescience,medical which has lost its consistency through Inhibitors,research,lifescience,medical shearing [4, 5]. The area surrounded between ascending and descending curves that is called hysteresis loop can give information about the structure breakdown and
rebuilding [4, 6, 7]. Controlled flocculation and rheologic modification are important factors in preparation of suspensions. Flocculated suspensions are settled rapidly to form large loose and easily dispersible sediments . Non-Newtonian polymers are utilized in the industries such as food, textile, pharmaceutical, and cosmetics. They are employed in suspensions as structural vehicles and exhibit non-Newtonian (plastic or pseudoplastics) flow with some degree of thixotropy. Various types of polymers are used as 4-Aminobutyrate aminotransferase rheology control agents such as CMC, methylcellulose, NaCMC, PVP, xanthan gum [6, 9–11], poloxamer , tragacanth , chitosan , and Veegum . Acetaminophen is an analgesic and antipyretic agent whose oral delivery especially to children is combined with trouble due to bitter and unpleasant taste. One of the methods to achieve the maximum taste masking characteristic is to formulate the drug in suspension form which creates a physical fence around the drug [15, 16].