Diabetes Care 22:1462–1470PubMedCrossRef 14. Stumvoll M, Mitrakou A, Pimenta W et al (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23:295–301PubMedCrossRef 15. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ (2001) A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care Selleck Epacadostat 24:539–548PubMedCrossRef 16. Ahren B,
Pacini G (2004) Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess β cell function in clinical studies. Eur J Endocrinol 150:97–104PubMedCrossRef 17. Muniyappa R, Lee S, Chen H, Quon MJ (2008) Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 294:E15–E26PubMedCrossRef 18. Gundberg CM, Looker AC, Nieman SD, Calvo MS (2002) Patterns of osteocalcin and bone specific GDC-0994 chemical structure alkaline phosphatase by age, gender, and race or ethnicity. Bone 31:703–708PubMedCrossRef 19. Ferron M, Wei J, Yoshizawa T et al (2010) Insulin signaling in osteoblasts integrates bone MI-503 remodeling and energy metabolism. Cell 142:296–308PubMedCrossRef 20. Aonuma H, Miyakoshi N, Hongo M, Kasukawa Y, Shimada Y (2009) Low serum levels of undercarboxylated osteocalcin in postmenopausal osteoporotic women receiving an inhibitor of bone resorption. Tohoku J Exp Med
“Introduction Approved therapies for treating osteoporosis in Canada include bisphosphonates (alendronate, etidronate, risedronate, and zoledronic acid), calcitonin, denosumab, raloxifene, and Resveratrol teriparatide . Each drug is effective in reducing vertebral fracture risk; however, only selected bisphosphonates (alendronate,
risedronate, and zoledronic acid), denosumab, and teriparatide have demonstrated significant reductions in nonvertebral fracture risk compared to placebo [2, 3]. Consequently, Canadian osteoporosis practice guidelines recommend etidronate, calcitonin, and raloxifene in a list of second-line options . In contrast to practice guidelines, many publicly funded drug plans across Canada limit coverage for first-line therapies, yet provide unrestricted coverage for etidronate—a second-line therapy . We used data from British Columbia (BC) and Ontario to compare osteoporosis treatment prescribing practices between provinces. In BC, etidronate is the only osteoporosis medication listed under general benefits on its provincial drug formulary (PharmaCare). In Ontario, etidronate has been available without restriction since 1996, while alendronate and risedronate were initially subject to limited access criteria until 2007, when coverage broadened to include all three oral bisphosphonates without restriction. Other osteoporosis therapies are not listed on either public formulary or are only available under restricted conditions.