In addition, the percentage of women with a history of IDU as well as the proportion of women who reported smoking during pregnancy declined
with calendar year, whereas maternal age and the proportion of Black women increased over time. Table 1 shows pregnancy outcomes in relation to type of ART exposure during pregnancy (analysis 1). The median gestational age was 39 weeks in women who did not receive ART as compared with 38 weeks in those receiving mono/dual therapy or cART, respectively. The cumulative distribution of gestational age by type of ART exposure is shown in Figure 3 and differed buy Talazoparib between groups (log-rank χ2=227.82; P<0.0001). The median birth weight of the children was about 170 g higher in women not receiving ART as compared with those receiving ART, while there was no difference
in child birth weight between women who received mono or dual ART and those who received cART (Table 1). Premature birth rates increased from 15.8% before 1994 to 28% after 1998, and were 15, 20 and 24% for woman receiving no therapy, mono or dual therapy, and cART, respectively. The odds ratios for prematurity in women receiving mono or dual therapy and cART as compared with women who did not receive ART during pregnancy were 1.8 (95% CI 0.85–3.6) and 2.5 (95% CI 1.4–4.3) (likelihood ratio test; P=0.0025; Table 1). The numbers of extreme premature births<32 weeks of gestation were 9 (1.4%), 4 (2.6%), and 11 (2.5%) in the no treatment, mono/dual and cART treatment groups, respectively. A total of 418 women on cART included in both the SHCS and the MoCHiV Epigenetics Compound Library (analysis 2) started treatment before (n=214) or during (n=204) pregnancy. The median duration of gestation was 37.5 weeks and was not related to the timing of the start of cART. Prematurity rates were 23 and 26% in women starting
cART before and during pregnancy, respectively. The corresponding odds ratio was 1.21 (95% CI 0.54–2.72) and this was not statistically significant. There was also no relationship between the total time on cART before Inositol oxygenase and during pregnancy and the risk of premature birth (random effects linear regression; P=0.53) or the duration of gestation (data not shown) (analysis 3). Taking the risk of prematurity for starting cART in the third trimester of pregnancy as the reference, the odds ratios for starting cART in the first or second trimester and before pregnancy were 1.56 (95% CI 0.25–9.8) and 1.72 (95% CI 0.33–8.96), respectively. We finally investigated a number of maternal risk factors for premature birth in women with complete data (analysis 4) who were registered in the SHCS. The unadjusted and adjusted odds ratios for the risk of prematurity comparing women receiving cART with women receiving mono or dual therapy during pregnancy were very similar, namely 5.35 (95% CI 0.33–87.5) and 3.87 (95% CI 0.23–63.