001). In regard to overall survival (OS), the patients who had optimal cytoreductive surgery exhibited improved OS results compared to the sub-optimal surgery group (42 vs. 27 months; P < 0.001). However, a Cox model analysis indicated that a greater number of maintenance chemotherapy cycles was a surrogate marker for improved OS (P < 0.001), but surgery type was not (P > 0.05). Duration of overall patient
follow-up exceeds 41 months.
Conclusion In advanced ovarian cancer patients who achieve a CCR following induction chemotherapy, optimal cytoreduction may confer a greater clinical benefit from a maintenance approach compared to suboptimal cytoreduction.”
“In this study, the effect of ultrahigh pressure extraction at pressures of 150 MPa, 250 MPa, 350 MPa and 450 MPa on the total phenolic contents, the extraction yields and the antioxidant activities
of green tea were investigated. The antioxidant activities Pfizer Licensed Compound Library of these extracts were analyzed using DPPH radical scavenging activity and total antioxidant capacity. The results showed that the phenolic contents and the antioxidant activities of extracts were greatly click here influenced by high pressure. The total phenolic contents and the antioxidant activities of ultrahigh pressure extraction at 450 MPa were higher than those of other ultrahigh pressure extraction and conventional extraction. The high content of phenolic compounds in the green tea leaves could account for the antioxidant activity. This study indicated that this new technology can benefit the food and pharmaceutical industries. (C) 2011 Elsevier Ltd. All rights reserved.”
“Objective To explore and compare the differences in the clinicopathological characteristics and prognosis of synchronous primary endometrial and ovarian cancers with primary endometrial cancer metastatic to adnexa.
Materials and methods Between January 1997 and December 2009,
https://www.selleckchem.com/HDAC.html 51 cases with endometrial cancer simultaneously with adnexa malignancy were identified. Among them, there were 18 cases with synchronous primary cancers of the endometrium and ovary (Group A) and 33 cases with primary endometrial cancer metastatic to the adnexa (Group B). Clinical and pathologic information was obtained from medical records. Parametric methods were used to compare clinical and pathologic features. Kaplan-Meier survival analysis was performed and compared using log-rank test.
Results The mean age at diagnosis of the disease was 56.6 +/- A 10.8 years (range 34-76 years) in Group A and 53.1 +/- A 9.5 years (range 37-76 years) in Group B. The two groups’ distribution of preoperative image findings, size of endometrial lesion, myometrial invasion, unilateral or bilateral, cervix invasion, and postoperative radiation existed significant differences. With a mean follow-up time of 4.3 +/- A 3.4 years (range 2-11 years), 5-year overall survival (OS) was 75 and 56% in Groups A and B, respectively (p = 0.034).