6 55–59 21 31 1.5 60–64 46 57 1.2 65–69 99 103 1.0 70–74 215 273 1.3 75–79 348 527 1.5 80–84 602 1,059 1.8 85+ 477 1,377 2.9 Vertebral 50–54 50 219 4.4 55–59 111 313 2.8 60–64 165 516 3.1 65–69 95 564 5.9 70–74 226 874 3.9 75–79 450 1,205 2.7 80–84 594 2,119 3.6 85+ 954 2,689 2.8 The fracture incidence of Chinese subjects was compared to those of the GDC-0068 Swedish and Japanese populations. The incidence rates of hip fractures in Caucasian men and women rose exponentially with age, whereas the rise was near linear for vertebral fractures.
In contrast, for Asian women in Hong Kong and Japan, the incidence rate for vertebral fractures rose exponentially with age, whereas the rise was near linear for hip fractures. In Asian men, both the incidence rates of vertebral and hip fractures rose near linearly with age. The hip fracture incidences in Hong Kong men and women were similar to those of Japan but much lower than those of the Caucasian population in Sweden. For example, the hip fracture rates for Hong Kong men and women CB-839 mw aged 65 to 69 years old were only 49% and 33%, respectively, of those of the Caucasian men and women in the same age group. However, the incidence of vertebral fractures in Asian men was similar to that of Caucasian
men; and Asian women have a much higher vertebral fracture incidence than Caucasian women (Fig. 1a and b). Although over vertebral fractures occur with a higher incidence earlier in life than hip fractures in both Asians and Caucasians, Asians have a much higher spine-to-hip fracture ratio than Caucasians,
meaning vertebral fractures have a higher proportion to hip fractures in Asians than in Caucasians, especially among subjects younger than 65 years (Table 3). Table 3 Age- and sex-specific clinical click here vertebral-to-hip fracture ratio in Hong Kong compared to Japanese and Swedish Caucasians Men Women Age group Japan [24] Hong Kong Sweden [28] Japan [24] Hong Kong Sweden [28] 50–54 3.9 5.0 2.2 N/Aa 13.7 2.6 55–59 7.1 5.3 1.4 4.7 10.1 2.9 60–64 2.8 3.6 3.2 8.9 9.1 1.6 65–69 4.1 1.0 1.2 6.3 5.5 1.4 70–74 3.5 1.1 1.7 3.4 3.2 1.4 75–79 2.3 1.3 1.0 2.8 2.3 0.8 80–84 1.8 1.0 0.6 2.6 2.0 0.5 85+ 1.7 2.0 0.7 1.7 1.1 0.4 aClinical vertebral-to-hip fracture ratio for Japanese women aged 50–54 was not available since the hip fracture incidence for this group was zero Discussion Vertebral fractures are the most common type of osteoporotic fractures, and they are well known as an independent predictor of future osteoporotic fractures, including both vertebral and non-vertebral fractures [22].