G 18 to 20 g, were purchased in 2008 and 0003 used in CP-690550 Tofacitinib the study. They were kept under standardized conditions of animal space. Standard mouse Ern Currency and clean water were made ad libitum. All animal experiments were carried out in accordance with the application of internationally recognized laboratories, animal care and starts Rte in the guidelines and rules of the Ethics Committee, South-Central University t of nationalities Th, China. The experimental treatment groups and MNR was injected intraperitoneally, and sodium selenite was administered orally. There were ten Mice in each group, and eight groups were used to Ver changes Of K To study rpergewichts. Group I served as saline with Solution-treated group. Mice In Groups II-VII, re U 0.1 ml of L Solution of sodium selenite on day 1 to day 18 victims, in which the DNR 3.
0 mg / kg was Given body weight. se, day 9, 11, 13, 15 and 17 intravenous Group VIII has once again MNR 3.0mg/kg U, K Body weight. only the days 9, 11, 13, 15 and 17 One day after the last dose of DNR were all the animals get Tet and samples were taken heart. deal positively Aminos acids found on every bill lateral CM molecules do mainly to the sharp decline in the SH of cysteine residues, Hesperidin inhibitor resulting in a loose conformation fluorescence changes t of CM. This study demonstrates that Se CM with k Combination can cause a decrease in fluorescence intensity and t the CM. But in the experiment on the effect of selenium on DNR fluorescent CM, the fluorescence intensity t erh Hen when exposed to selenite concentrationwas over 9 million, and an apparent Ph phenomenon Of red selenium was observed when the concentration reaches 20 selenite M.
Based on the binding constant, it is clear that selenium, compared with MNR may also friendships with CM. Therefore, the interaction of DNR seleniumcould competition with CMand inhibit shorten the time saved MNR in cardiac tissue, and protects against CM-induced Kardiotoxizit t of MNR. Furthermore, the results also show that the biological activity of SE, a red t had. Effect of selenium administration on the death of Co toxic effects of selenium on the response to MNR T induced are summarized in Table 1. Toxic death was dependent Ngig on the dose of DNR. All Mice died within 2 days after treatment in group 90 mg / kg DNR, but the 20 mg / kg group was relatively MNR’s R, for there were seven survivors Mice with normal behavior until 14 Day.
In combination with MNR Se in a dose of 90 mg / kg of the treatment, the lower dose of sodium selenite effective in eliminating the beautiful dlichen DNRinduced effects. The results show that selenium as sodium selenite, Mice Protected from acute toxicity, appropriate dosage T induced by h higher doses of DNR. Ver Change in BW, H / BW and LVM / BW The effects of selenium DNR alone or simultaneous administration of BW are H / BW and LVM / BW listed in Table 2. The administration of the DNR, no makeup caused a significant erh Increase the H / BW and LVM / BW in the treated mice M. Was associated with the data show that DNR induced Kardiotoxizit t with cardiac hypertrophy and ventricular Re remodeling. However, the significant increase in H / BW and LVM / BW was not observed when 0.5 Se 10.0 g / ml was administered together with the DNR. The results suggest that lower doses of selenium may have a protective effect on the reduction of DNR-induced cardigan