H HepG2 cells Fostamatinib R788 in the Achselh once t Resembled for 14 days, 2 weeks after tumor implantation. After treatment, tumors were excised and weighed. Statistics for each group of Mice, compared with the vehicle. Figure 2 Amonafide and numonafides Ver change The expression of genes Hnlichen patterns. Number of transcripts that are significantly in HepG2 cells by Illumina BeadArray s after treatment overnight with 2 M of each compound as compared to vehicle-treated cells and cells treated with Amn be determined VER Changed. Ver Change in the transcript levels are upregulated or significantly more than three times in cells treated with AMN or reduced numonafides of vehicles. AVERAGE 456 is more effective and less toxic than AMN Liu et al. Flight neoplasia.
13, No. 5, 2011 Due to the high toxicity of t with the NMA and NA observed and to compare the need for comparable doses over a liter Ngeren treatment period, was a different dosing strategy in the same used AGS and Huh7 xenograft models . about 100 mol / kg of each compound was administered intraperitoneally on day 7 to day / 7 days schedule for a total of four cycles of treatment. At 100 XL880 mol / kg, all three drugs inhibit tumor growth of F If after 7 days of the vehicle significantly, the tumor size E was in treatment groups was not significantly different from each other in 3 Numonafides are effective in xenograft models of liver and stomach cancer with different dosages. The subcutaneous xenograft of Huh7 shoulders and AGS cells and xenograft intraperitoneal Huh7 cells, the luciferase in mice Nacktm Implanted.
Two weeks after the implantation of subcutaneous xenografts and 1 week after the implantation of intraperitoneal xenografts were Mice with 50 mol / kg each AMN, year or average and 100 mol / kg once t Resembled AVERAGE treated for 28 consecutive days. Tumor burden is emitted determined by the total number of photons of luminescence tumors. Once the number of viable M Mice in a treatment group fell from three to six years, the analysis will not be displayed on the lots for the following days. Subcutaneous xenograft tumor size was E at M Mice significantly inhibited with the compound compared to vehicle-treated M Treated mice for 14 days. NMA tumor growth of F Is significantly more than 50 mol / kg and an average, but not more than 100 mol / kg on day 21 average.
For all treatments of intraperitoneal xenograft F Significantly inhibited the tumor growth as compared to vehicle comprises from day 7 to 21. The Mice were implanted with subcutaneous xenografts and AGS Huh7 or 100 mol / kg AMN, NA, and say with a cycle once a day for 7 days and without treatment for 7 days. All treatments significantly reduced the tumor growth compared to the control group after 7 days, but the tumor size E between the treatment groups was not significantly different on 21 Day. Flight neoplasia. 13, No. 5, 2011 median effective and less toxic than AMN Liu et al. 457 Figure 4 AVERAGE is much less toxic than AMN or NA. The survival of M Mice with an intraperitoneal injection of vehicle or 50, 100 or 200 mol / kg AMN, NA, MEDIUM or even t Resembled treated for 35 days. Weight of Mice with subcutaneous tumors with 50 mol / kg once t Was like for 49 consecutive days or 100 implanted mol / kg once per day on a cycle of 7 days and 7 days. Activity implanted t and stool consistency in M Mice with Huh7 xenografts. Once the number of viable M Mice in a Tre