The hypercalcemia is mediated
by extra-renal 1-alpha hydroxylation and is seen in other fungal infections in immunosuppressed patients. We suggest that PJP should be considered as a differential cause in unexplained PTH-independent hypercalcemia in renal transplant recipients even in the absence of respiratory symptoms. 288 INFECTIVE BURSITIS DUE TO MYCOPLASMA HOMINIS IN A SIMULTANEOUS PANCREAS KIDNEY TRANSPLANT RECIPIENT RS ELKHATIM1, CA MILTON1,3, DL GORDON2,3, JA BARBARA1,3, JY LI1,3 Department of 1Renal Medicine; 2Infectious Disease, Flinders Medical PF-6463922 Centre and 3School of Medicine, Flinders University, Adelaide, South Australia, Australia Background: Mycoplasma hominis is a common inhabitant of the genitourinary tract and recognized as an opportunistic pathogen. We report a case MAPK Inhibitor Library solubility dmso of infective bursitis due to M. hominis in a simultaneous pancreas kidney (SPK) transplant recipient. Case Report: A 39-year-old man with end stage renal failure secondary to diabetic nephropathy received SPK transplantation in November 2013. His post-transplant course was complicated by pancreatic graft loss due to arterial thrombosis.
Renal function has been stable (creatinine 76 μmol/L). Immunosuppressive therapy included tacrolimus, mycophenolate and prednisolone. Three weeks post-transplant, he developed a low grade fever, severe left hip pain and was unable to weight bear. The MRI showed an effusion in the trochanteric bursa with high T2 signal and oedema in the left gluteus and adductor muscles. The bursal fluid was aspirated and the culture grew M.
hominis. Muscle biopsy revealed no abnormality. He was treated with doxycycline which is planned for 6 months. He mobilized independently 4 weeks after treatment commenced. Conclusion: To the best of our knowledge, this is the first reported case of M. hominis causing bursitis in a transplant recipient. The combination of surgical manipulation of the urinary tract and immunosuppression places the renal transplant patient at high risk for Methamphetamine M. hominis infection. M. hominis lacks a cell wall, is not visualized on Gram stain and slow to grow in culture. Therefore, there is often a significant delay in diagnosis. It is important for clinicians to have high index of suspicion for atypical organisms whilst working up the cause of infection in immunosuppressed patients. The first choice antibiotic for M hominis is a tetracycline but the duration of therapy is not well established. 289 UNEXPLAINED NEPHROTIC-RANGE PROTEINURIA IN A CONSANGUINEOUS 2-YEAR-OLD BOY K BLAZE, T FORBES, C QUINLAN, A WALKER Royal Children’s Hospital, Melbourne, Victoria, Australia Background: We report a case of a consanguineous 26-month-old boy with a chromosome 2q35 deletion.