N of the calcium channel blocker, verapamil, the ben To do prior can not produce a reversal in vitro MDR-TB can be obtained in patients with Kardiotoxizit Th important. Valspodar biricodar and ARQ 197 Tivantinib showed a significant pharmacokinetic interactions with paclitaxel1, 3, 10, 11 Add biricodar to doxorubicin and vincristine treatment did not significantly increased Hen the antitumor activity of t or survival12. Previously, in an attempt to introduce new small molecules that are potent and selective inhibitors identified as MDR, we screened 2000 small molecule compounds by the NCI diversity set library for compounds that can reverse MDR in drug lines, resistant cells. We identified two compounds, tetrandrine on 2000 13 and 2 4 2 May quinolinyl piperidinyl methanol as connections with the h Chsten activity t as pregnancy agents5ter MDR reversal. PDT can be used also as an in vivo model for assessing response of the tumor in patients before of extraction unencumbered, ben unambiguously Term systemic chemotherapy after the surgery.
Most sharing plans are to anthracyclines or taxanes PST today, the s Rs were based and judged effectively in the phase III-studies. Nevertheless, despite the growing number of clinical studies, the PST, the optimal therapy has not been determined. In 2000, our group is an individualized treatment of DVT in patients with locally advanced breast cancer, which is composed of simple agents administered sequentially, according to the clinical efficacy. The aim of our study was the toxicity of t, effectiveness and outcome of this plan over a period of 7 years to evaluate. The patients and the study population and evaluation of pretreatment methods The study population included 102 patients with breast cancer participating in an hour Higher education, the University of t connected Medical Center in 2000, 2007, which were treated with our neoadjuvant regimen for reasons of preservation of the breast or inoperable disease at diagnosis. The scheme was also used to treat HER2-positive patients to be replaced until 2005, when he was replaced by a system with trastuzumab. Before treatment, the stage of the disease by k Rperliche examination, radiological assessment and metastatic work was to evaluate. Biopsy was not mandatory for lymph node staging of clearly pathological k Rperliche examination and imaging techniques, fine needle aspiration was diluted with knots Chtig made.
The left ventricular Re ejection fraction was assessed by echocardiography or gated multi takeover. The study was approved by our Institutional Review Board. All patients were treated with chemotherapy with doxorubicin 30 mg / m 2 / day for 3 consecutive days every 3 weeks. Their response was assessed every 6 three weeks. A complete clinical response, as no palpable tumor, and imaging was defined as a partial clinical response was a decline of 50% of the tumor size E in the k Defined rperlichen examination, imaging, or both. The toxicity was t classified according to the criteria of the National Cancer Institute Common Toxicity, version 3. These Survivin Signaling results were used to determine the number of treatment cycles. Patients with good clinical response was again U total of 4 courses. If the clinical completely Response to requests reference requests getting four G Lengths was achieved, the patient was referred for surgery. If a partial response was achieved after four G Lengths, was the treatment with paclitaxel 80 mg / m 2 is set.