In addition

to the diagnostics of intracranial vascular disease, this technique is valuable in intensive care and stroke units for follow-up examinations in vasospasm after subarachnoid hemorrhage and for intraoperative monitoring. In difficult anatomical conditions, the application of echo contrast agents can improve the diagnostic reliability of the examination. Based on advances in computer and transducer technology http://www.selleckchem.com/products/obeticholic-acid.html TCCS as a noninvasive method has a great potential in further innovative imaging and therapeutic solutions such as cerebral perfusion imaging, sonothrombolysis, and site targeted ultrasound contrast agents for drug delivery to the brain. “
“The National Institute of Neurological Disorders and Stroke trial of recombinant tissue plasminogen activator (tPA) showed that JQ1 intravenous thrombolysis with acute ischemic stroke within 3 h from onset had favorable clinical recovery compared with placebo-treated patients [1]. However, a thrombolytic effect was not evaluated with monitoring of occlusion artery in this study. Cerebrovascular ultrasonography was useful clinically for evaluating cerebral hemodynamics rapidly and in real-time for the patients with acute ischemic stroke compared with magnetic resonance angiography (MRA). The timing and speed of recanalization after (tPA) therapy monitoring by transcranial Doppler (TCD) correlates with clinical recovery [2] and [3]. These real-time flow informations are

useful in developing next therapies and in selection for interventional treatment. The aim of this study was to analyze if the patients had early recanalization or not using transcranial color-coded sonography (TCCS) in order to evaluate the usefulness of real-time monitoring in systemic thrombolysis. Dipeptidyl peptidase Consecutive patients who had acute ischemic stroke with intravenous tPA within 3 h from onset between April 2010 and January 2011 were included in this study.

tPA was administered in a dose of 0.6 mg/kg (10% bolus, 90% continuous infusion during 1 h) according to Japanese standard protocol [4]. The patients with insufficient acoustic window were excluded. An experienced neuro-sonographer performed all TCCS studies using a EUB-7500 or 8500 with a 2 MHz sector transducer (S50A, HITACHI Medical Corporation, Japan). We evaluated occlusion of intracranial arteries from transtemporal or suboccipital window by TCCS with Thrombolysis in Brain Ischemia (TIBI) flow-grading system [5] and monitored residual flow in real-time every 15 min until 120 min after the t-PA bolus. An insonation time with TCCS was not longer than 5 min in each examination. No head frame was used during insonation. Complete recanalization was defined as TIBI 0–3 to 5, and partial recanalization was defined as TIBI 0–2 to 3. National Institutes of Health Stroke Scale (NIHSS) scores were obtained before tPA treatment, every 15 min until 1 h and every 30 min after 1 h by a neurologist.