8 −0.030 −0.056* −0.065** −0.061* Femoral neck area (cm2) 5.52 ± 0.39 −0.022 −0.034 −0.028 Lorlatinib mw −0.015 Radius non-dominant area (cm2) 17.4 ± 1.9 −0.053 −0.076** −0.094*** −0.091** pQCT Radius cortical vBMD (mg/cm3) 1,164 ± 23 −0.009 −0.010 −0.025 0.005 Radius cortical CSA (mm2) 96.1 ± 11.7 −0.073* −0.068** −0.064* −0.046 Radius periosteal circumference (mm) 42.1 ± 2.9 −0.098** −0.093*** −0.079** −0.158*** Radius endosteal circumference (mm) 23.8 ± 3.1 −0.093** −0.093** −0.144*** −0.185*** Radius trabecular vBMD (mg/cm3) 219 ± 41 −0.014 0,010 0.019 −0.007 Table 2

Mean values and standard deviations. Bivariate Selleck Vismodegib correlation with maternal age was assessed using Pearson’s correlation. r values are presented. Standardized β-coefficients were assessed using a stepwise linear regression model a n = 1,009 b n = 997, adjusted for calcium intake, current level of physical activity, adult height and weight, birth height, total body adipose tissue and lean mass, length of pregnancy, and present smoking in the offspring c n = 907, adjusted for calcium intake, current level of physical activity, adult height and weight, birth height, total body adipose tissue and lean mass, length of pregnancy, present smoking in the offspring, SEI-index, maternal parity, maternal smoking, and

paternal age d n = 705, adjusted for calcium intake, current level of physical activity, GSK872 price adult height and weight, birth height, total body adipose ADAMTS5 tissue and lean mass, length of pregnancy, present smoking in the offspring, SEI-index, maternal parity, maternal smoking, paternal age, maternal weight prior to pregnancy, and maternal

height *p < 0.05, **p < 0.01, ***p < 0.001 Bivariate correlations between maternal age and characteristics of the young men and other parental characteristics Maternal age was directly correlated to socioeconomic status in 1985, parity and paternal age while it was inversely correlated to the current level of physical activity in the offspring, length of pregnancy, and smoking in early pregnancy (Table 3). Table 3 Associations between maternal age, anthropometrics and parental variables, and other related variables Variables Maternal age (years) Offspring characteristics r value p value  Age (year) −0.044 0.166  Height (cm) 0.060 0.056  Weight (kg) −0.056 0.075  Calcium intake (mg/day) −0.019 0.545  Smoking (yes/no) −0.061 0.051  Physical activity (hours/week) −0.063 0.047  Total body adipose tissue (kg) −0.059 0.061  Total body lean mass (kg) −0.012 0.693  Birth height (cm) 0.045 0.154  Birth weight (g) 0.054 0.093 Parental characteristics  Socioeconomic index 1985 0.341 <0.001 Maternal characteristics  Length of pregnancy (day) −0.087 0.006  Parity (n) 0.392 <0.001  Weight before pregnancy (kg) 0.027 0.415  Height (cm) 0.008 0.810  Smoking in early pregnancy (yes/no) −0.106 0.001  Caesarian section (yes/no) 0.058 0.067 Paternal characteristics  Age (year) 0.670 <0.001 Table 3 Pearson’s correlation were used.