Although it is accepted that myeloma cells mediate bone destruction by inhibition of osteoblasts and activation of osteoclasts, the underlying Apoptosis inhibitor mechanism is still poorly understood. This study demonstrates that constitutive activation of p38 mitogen-activated protein kinase in myeloma cells is responsible for myeloma-induced osteolysis. Our results show that p38 is constitutively activated in most myeloma cell lines and primary myeloma cells from patients. Myeloma cells with high/detectable p38 activity, but not those with low/undetectable p38 activity, injected into severe combined immunodeficient

(SCID) or SCID-hu mice caused bone destruction. Inhibition or knockdown of p38 in human myeloma reduced or prevented myeloma-induced osteolytic bone lesions without affecting tumor growth, survival, or homing to bone. Mechanistic studies showed that myeloma cell p38 activity inhibited osteoblastogenesis and bone formation and activated

osteoclastogenesis and bone resorption in myeloma-bearing SCID mice. This study elucidates a novel molecular mechanism-activation of p38 signaling in myeloma cells-by which myeloma cells induce osteolytic bone lesions, and indicates that targeting myeloma cell p38 may be a viable approach to treating or preventing myeloma bone disease.”
“Drought and high salinity are two major abiotic stresses affecting crop productivity. Therefore, the development of crops better adapted to cope with these stresses represents a key goal find more to ensure global food security to an increasing world population.

Although many genes involved in the response to these abiotic stresses have been extensively characterised and some stress tolerant plants developed, the success rate in producing stress-tolerant crops for field conditions has been thus far limited.

In this review we discuss different factors hampering the successful transfer of beneficial genes from model species to crops, emphasizing some limitations in the phenotypic characterisation and definition of the stress tolerant plants developed so far. We also highlight some technological advances and different approaches that may help in developing cultivated stress tolerant plants.”
“Using a spatial cueing paradigm with emotional and neutral facial expressions as cues, we examined early and late patterns of information why processing in cognitive avoidant coping (CAV). Participants were required to detect a target that appeared either in the same location as the cue (valid) or in a different location (invalid). Cue-target onset asynchrony (CTOA) was manipulated to be short (250 ms) or long (750 ms). CAV was associated with early facilitation and faster disengagement from angry faces. No effects were found for happy or neutral faces. After completing the spatial cueing task, participants prepared and delivered a public speech and heart rate variability (HRV) was recorded. Disengagement from angry faces was related to a decrease in HRV in response to this task.