Reaction of hydroxy-terminated poly(e-caprolactone) (PCL) with DTDPA quantitatively yielded DTDPA functionalized PCL (PCL-S-S-COOH). The disulfide-containing polyester was regioselectively conjugated onto the hydroxy groups of chitosan under mild and homogeneous conditions, utilizing dodecyl sulfate-chitosan complexes (SCC) as an intermediate. The self-assembly and Doxorubicin (Dox)

release behavior of the copolymers were investigated. Spherical micelles could be formed through self-assembly of CS-S-S-PCL in aqueous media. The reduction-sensitive behavior of CS-S-S-PCL micelles was investigated by using Dithiothreitol (DTT) as a reductive reagent. In the presence of 10 mM DTT, the micelles gradually lost their aggregation stability and were precipitated out after four days. In addition, the Dox release was accelerated when the micelles were treated ATM/ATR mutation with DTT. (c) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“Background: Adrenocortical tumors (ACTs) are rare in children. Because of the rarity and various manifestations of ACTs, patients of ACTs are not easily diagnosed. Some patients were misdiagnosed before surgery.

Objective: Identify the clinical, laboratorial, imaging and histopathological characteristics of adrenocortical check details tumors in children. Compare adrenalcortical adenoma

with carcinoma.

Methods: A retrospective review of 34 identified patients who were younger than 15 years old with histologic confirmation of adrenocortical carcinoma (ACC) or adenomas from 1991 to 2010.

Results: In these 34 patients, 19 were adrenocortical adenoma (ACA) and 15 were ACC. The median age at diagnosis was 3.33 years (range, 0-16 years), and 70.6% of the patients were younger than five years. Girls slightly predominated MLN4924 in vivo over boys (1.4:1). For endocrine abnormality, 14 patients had isolated precocious puberty, five patients had isolated Cushing syndrome, 10 patients had precocious puberty

plus Cushing syndrome, and five patients did not have any symptoms. The most frequent findings in laboratory tests were disturbance of the normal circadian rhythm of cortisol secretion (93.8%), followed by elevated serum level of testosterone (89.7%). Only 3.8% of ultrasound diagnosis and 12.1% of computed tomography (CT) diagnosis were consistent with pathologic diagnosis.

Conclusion: Different from those in adult, the most frequent presentation in children with ACTs is peripheral precocious puberty with or without Cushing syndrome, and isolated Cushing syndrome. Few present with non-functional local mass. Laboratory tests usually reveal the discordantly elevated serum levels of sexual corticosteroid hormones, change of diurnal rhythm of cortisol or increase of morning cortisol.