0% in 2007 to 32.6% in 2011. The proportion of the population that underwent CPR training within the previous 2 years increased significantly from 26.9% to 49.0%. The factors most related

with intention of bystander CPR were male gender, younger age, CPR awareness, recent CPR training, and qualified CPR learning. In 2011, 75.8% of respondents were more willing to perform bystander CPR for stranger vs. 68.3% in 2007 (p = 0.002). Additional dispatcher hands-only CPR increased this proportion (85.8%, p < 0.001). However, bystander CPR experience rates remained unchanged (3.6-3.9%).

Conclusion: Changes in nationwide CPR policies and systemic factors affected citizens’ awareness and willingness to perform bystander VX-661 research buy CPR. Additionally, applied BAY 57-1293 clinical trial dispatcher hands-only CPR and publicity increased public willingness to perform bystander CPR. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“A large number of risk alleles have been identified for multiple sclerosis (MS). However, how genetic variations may affect pathogenesis remains largely unknown for most risk alleles. Through direct sequencing of CD24 promoter region, we identified a cluster of 7 new single nucleotide polymorphisms in the CD24 promoter. A hypermorphic haplotype consisting of 3 SNPs was identified through association studies consisting of 935 control and 764 MS patients (P=0.001,

odds ratio 1.3). The variant is also associated with more rapid progression of MS (P=0.016, log rank test). In cells that are heterozygous for the risk allele, chromatin immunoprecipitation revealed that risk allele specifically bind to a transcription factor SP1, which is selectively required for the hypermorphic promoter activity of the variant. In MS patients, the CD24 transcript levels associate with the SP1-binding variant in a dose-dependent manner (P=7×10(-4)). Our data revealed a potential role for SP1-mediated transcriptional regulation in MS pathogenesis.”
“Background and Purpose: Current IGF-1R inhibitor guidelines recommend routine second transurethral resection (TUR) for accurate diagnosis and to prevent understaging of muscle-invasive bladder cancer. We evaluated the diagnostic

accuracy of immediate second resection of the tumor bed during initial TUR and its prognostic significance.

Patients and Methods: Patients (n = 126) undergoing TUR were prospectively randomized to undergo (n = 63) or not undergo (n = 63) immediate second resection of the tumor bed after complete TUR. Second resection was repeated until muscularis propria (MP) was identified in the specimen and the depth of tumor invasion was inspected. The results of second resection were compared with final pathology results for diagnostic accuracy. Recurrence and progression rates were compared in the two groups, and factors affecting recurrence were evaluated.

Results: Patient age, sex distribution, number of tumors, pathologic T stage and grade were similar in the groups.