210 0.688 1.03 (0.90–1.18)  rs2804916a T>C 0.170/0.166 0.157/0.163 0.921 0.99 (0.84–1.17) 0.138/0.135 0.971 0.997 (0.86–1.16)  rs2804918a A>G 0.345/0.357 0.352/0.333 0.847 1.01 (0.89–1.15) 0.318/0.321 0.896 1.01 (0.90–1.13)  rs9370232a G>C 0.361/0.370 0.358/0.362 0.640 0.97 (0.86–1.10) 0.357/0.346 0.797 0.99 (0.88–1.10)  rs4712047a G>A 0.494/0.477 0.448/0.505

0.221 0.93 (0.82–1.05) 0.456/0.457 0.269 0.94 (0.84–1.05)  rs3734674 G>A 0.158/0.171 0.191/0.149 0.252 1.10 (0.93–1.29) 0.176/0.188 0.416 1.06 (0.92–1.23)  rs11751539a A>T 0.309/0.320 0.302/0.312 0.476 0.95 (0.84–1.09) 0.315/0.276 0.955 0.997 (0.87–1.12)  rs3757261a G>A 0.155/0.165 0.184/0.139 0.159 1.12 (0.95–1.32) 0.168/0.174 0.252 1.09 (0.94–1.26)  Semaxanib cost rs2253217a A>G 0.063/0.071 0.056/0.068 0.210 0.85 (0.67–1.09) 0.045/0.061 0.111 0.83 (0.67–1.04) Haplotype

 Block 1   GT 0.641/0.637 0.629/0.645 0.666 0.97 (0.86–1.10) 0.665/0.655 0.796 0.99 selleck products (0.88–1.10)   TT 0.189/0.196 0.215/0.192 0.519 1.05 (0.91–1.22) 0.198/0.210 0.711 1.03 (0.90–1.17)   GC 0.171/0.167 0.156/0.163 0.086 0.87 (0.74–1.02) 0.137/0.135 0.949 0.995 (0.86–1.15)  Block 2   GAGA 0.471/0.442 0.446/0.478 0.904 0.99 (0.88–1.12) 0.468/0.491 0.674 0.98 (0.88–1.09)   GTGA 0.311/0.320 0.313/0.312 0.758 0.98 (0.86–1.11) 0.313/0.272 0.734 1.02 (0.91–1.14)   AAAA 0.154/0.166 0.184/0.139 0.150 1.12 (0.96–1.32) 0.169/0.174 0.239 1.09 (0.94–1.26)   GAGG 0.061/0.067 0.054/0.061 0.353 0.89 (0.70–1.14) 0.042/0.050 0.280 0.88 (0.70–1.11) Block 1; rs9382227, rs2804916 Block 2; rs3734674, rs11751539, rs3757261, rs2253217, rs2841514 aTag SNPs Table 6 Association between SNPs in SIRT6 and diabetic nephropathy   Screening Library cost Allele frequencies (nephropathy case−control) Proteinuria ESRD Combined Study 1 Study 2 P OR (95% CI) Study 3 P OR (95% CI) SNP  rs350852a T>C 0.313/0.338 0.313/0.303 0.545 0.96 (0.84–1.09) 0.324/0.348 0.367 0.95 (0.84–1.06)  rs7246235a T>G 0.185/0.186 0.168/0.209 0.110 0.88 (0.75–1.03) Edoxaban 0.202/0.164

0.447 0.95 (0.82–1.09)  rs107251a C>T 0.296/0.315 0.305/0.291 0.841 0.99 (0.87–1.12) 0.323/0.328 0.799 0.98 (0.88–1.11)  rs350844 G>A 0.304/0.322 0.309/0.291 0.936 0.99 (0.87–1.13) 0.336/0.347 0.819 0.99 (0.88–1.11) Haplotype  Block 1   TCG 0.516/0.499 0.529/0.500 0.122 1.10 (0.98–1.24) 0.517/0.532 0.342 1.05 (0.95–1.17)   TTA 0.299/0.318 0.303/0.291 0.776 0.98 (0.86–1.12) 0.360/0.342 0.713 0.98 (0.87–1.10)   GCG 0.185/0.183 0.168/0.209 0.100 0.88 (0.76–1.02) 0.067/0.052 0.433 0.95 (0.83–1.09) Block 1; rs7246235, rs107251, rs350844 aTag SNPs Table 7 Replication study for the association between SNPs in SIRT1 and diabetic nephropathy   Allele frequencies (nephropathy case−control) Proteinuria (study 1, 2, 4) Proteinuria + ESRD (study 1, 2, 3, 4) Study 4 P OR (95% CI) P OR (95% CI) SNP  rs12778366a T>C 0.089/0.131 0.676 0.96 (0.81–1.15) 0.448 0.94 (0.80–1.10)  rs3740051a A>G 0.311/0.291 0.226 1.08 (0.96–1.21) 0.106 1.09 (0.98–1.22)  rs2236318a T>A 0.113/0.116 0.350 0.92 (0.78–1.09) 0.257 0.91 (0.78–1.07)  rs2236319 A>G 0.360/0.344 0.142 1.09 (0.