578, df = 8, p < 0.001). Table 1 Demographics of respondents (n varies due to incomplete responses) Characteristic Number (percentage) Country of practice  France 236 (20.2)  Germany 251 (21.5)  Netherlands 254 (21.7)  Sweden 262 (22.4)  UK 165 (14.1) Gender  Male 764 (65.4)  Female 404 (34.6) Age group  ≤50 years 572 (49.0)  >50 years 596 (51.0) Years in practice  ≤10 182 (15.6)  11–20 466 (39.9)  >20 520 (44.5) Patients seen per week  <25 33 (2.9)  26–50 133 (11.5)  51–100 358 (31.0)  101–150 309 (26.8)  151–200 199 (17.2)  >200 122 (10.6) PFT�� Highest level of education in genetics  None

224 (19.2)  Undergraduate 680 (58.2)  During specialist training 53 (4.5)  CME 172 (14.7)  Further degree 32 (2.7)  Missing 7 (0.6) Value of

undergraduate training (n = 880)  Useful 538 (61.1)  Useless 342 (38.9) Value of specialist training (n = 71)  Useful 61 (85.9)  Useless 10 (14.1) Value of CME (n = 172)  Useful 164 (95.3)  Useless 8 (4.7) Table 2 Highest level of education by years in practice   Undergraduate Specialist CME Degree None Total ≤10 years 130 16 19 4 12 181 11–20 years 309 18 60 10 65 462 >20 years 241 19 93 18 147 518 Total 680 53 172 32 224 1161 Numbers of respondents willing to carry out each of the tasks themselves is shown in Table 3. Most (61%) expected to take a family history, and a significant minority (38%) were willing Savolitinib to explain an inheritance pattern. However, only 10.3 (28%) were willing to carry out any other tasks. Univariate analysis of factors predicting likelihood of carrying out tasks oneself is shown in Table 4. Factors which remained significant at multivariate

analysis are shown in Table 5. Only country of practice and gender were consistently predictive of willingness to carry out more complex tasks, with French/German and male GPs showing more willingness. Table 3 Willingness to carry out tasks oneself Task Number willing to perform task Percentage Taking a family Celecoxib history 717 61.4 Explaining the inheritance pattern 445 38.1 Explaining the genetic risk to Mr Smith’s children 327 28 Giving information about available genetic tests 258 22.1 Informing Mr Smith of the implications of no mutation being found 316 27.1 Informing Mr Smith of the implications of a mutation being found 169 14.5 Ordering the genetic test 183 15.7 Explaining the test results 129 11 Explaining the implications of the test results for Mr Smith’s children 120 10.3 Table 4 Univariate analysis Task Variable Odds ratio for doing oneself (95% CI) Taking a family history Country (reference UK)  France 0.59 (0.39–0.90)  Germany 2.07 (1.33–3.23)  Netherlands 0.20 (0.13–0.30)  Sweden 2.41 (1.54–3.79) Gender (reference male)  Female 1.25 (0.98–1.61) Age (reference >50)  ≤50 0.73 (0.57–0.92) Years in practice (reference >20)  11–20 0.90 (0.69–1.16)  ≤10 0.93 (0.66–1.32) Highest genetic education (reference none)  Undergraduate 1.45 (1.07–1.98)  During specialist training 1.67 (0.88–3.18)  CME 0.52 (0.35–0.