Across ages and sexes, use of alcohol and tobacco tended to indicate lower trait levels than use of marijuana, other controlled substances, and uncontrolled substances. All substances provided a similar amount of information on the underlying dimension (except for uncontrolled substances, which provided the least information). This suggests that measurement and interpretation of adolescent substance use is enhanced by the consideration of a wide range of substances. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“Background: Little is known about the prevalence of Staphylococcus aureus nasal colonization and the epidemiology of methicillin-susceptible
and methicillin-resistant S. aureus (MRSA) among cystic fibrosis (CF) patients and their household members.
Objectives: We sought to determine the epidemiology of S. aureus among children and adolescents Z-DEVD-FMK cost with CF and their household members.
Methods: Three CF centers enrolled case subjects with at least 1 MRSA-positive respiratory tract culture from 2001 to 2006 and control subjects with MRSA-negative cultures. S. aureus isolates from the anterior nares Emricasan datasheet of CF subjects and their
household members were assessed for staphylococcal chromosomal cassette (SCC) mec type. Strain similarity was determined by pulsed-field gel electrophoresis.
Results: S. aureus nasal colonization occurred in 52.4% (22/42), 27.0% (17/63), and 25.0% (72/288) of case, control, and household participants, respectively. Case subjects and their contacts were more likely to harbor MRSA in their nares and be from a multipatient CF family. Of 31 MRSA strains, 10 (32.3%) were SCCmec type IVa, associated with community-acquisition. Overall, 27.6% of 98 households had 2 members colonized with closely related isolates. Household members were equally likely to be colonized with closely related strains of MRSA (20/31, 65%) versus MSSA (38/80,
48%).
Conclusions: This study demonstrated that household members of CF children harbor both MSSA and MRSA, including CA-MRSA, and that S. aureus is transmitted within CF households. Carriage of S. aureus by household members of CF children may have implications for infection control and treatment strategies. CBL0137 supplier Future studies should monitor the distribution and virulence of SCCmecA types in patients with CF.”
“Study of interactions between drugs and target proteins is an essential step in genomic drug discovery. It is very hard to determine the compound-protein interactions or drug-target interactions by experiment alone. As supplementary, effective prediction model using machine learning or data mining methods can provide much help. In this study, a prediction method based on Nearest Neighbor Algorithm and a novel metric, which was obtained by combining compound similarity and functional domain composition, was proposed.