At baseline 37.9 % of patients had experience with non-pharmacological treatments and 87.0 % at 12-month follow-up. In conclusion, an integrated headache care program was successfully established. Positive health-related outcomes could be obtained with a multidisciplinary out- and inpatient headache treatment program.”
“Background and objective: The biosafety of hydroquinone and its derivatives as skin whitening agent remains

controversial. Here, we investigated the effects of hydroquinone, arbutin, and deoxyarbutin (D-arb) on melanogenesis and antioxidation Using Cultured melan-a melanocytes in the presence or absence of ultraviolet A (UVA)-induced oxidative stress and determined whether D-arb enables to be an alterative to hydroquinone and arbutin for skin whitening use.

Methods: D-arb was synthesized ill this Study Thiazovivin solubility dmso by removing all hydroxyl groups from the glucose side-chain of arbutin. Tyrosinase activity was measured by (14)C-tyrosine incorporation, the intracellular reactive oxygen species (ROS) level was monitored by H(2)DCFDA fluorescence labeling, and [lie cell viability was determined by MTT assay in murine melan-a melanocytes treated with hydroquinone, arbutin

and deoxyarbutin in the presence or absence of UVA-induced EGFR targets oxidative stress.

Results: The cytotoxicity of hydroquinone and arbutin except for D-arb was increased while the cells exposed to a nontoxic dose (3 J/cm(2)) of UVA irradiation. Suppressed ROS generation was noted by the treatment Of D-arb to compare with arbutin and hydroquinone. All three compounds had a similar inhibition oil tyrosinase activity in dose-dependent manners with two- to three-fold decreases over the untreated control. There was no change in expression of tyrosinase protein in cells treated

with arbutin or hydroquinone, but a decreased protein expression of tyrosinase was seen in deoxyarbutin-treated cells.

Conclusions: Deoxyarbutin exerts potent tyrosinase inhibition, lessened cytotoxicity, and certain antioxidation HDAC inhibitor mechanism potential, may serve as an effective and safe alternative to hydroquinone for use in skin whitening. (C) 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.”
“Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day).