“
“Background: Post-occlusive hyperemia is often BI-D1870 molecular weight used as a paradigm to evaluate vascular reactivity, for example by measuring post-ischemic flow-mediated dilation, arterial blood flow or temporally

resolved venous blood oxygenation (HbO(2)). Here we demonstrate the feasibility of a simultaneous measurement of blood flow and HbO2 in the femoral circulation as part of a single procedure.

Methods: A multi-echo GRE pulse sequence was designed and implemented to collect velocity-encoded projections in addition to full-image echoes for field mapping as a means to quantify intravascular magnetic susceptibility. The method’s feasibility was evaluated at 3T in a small pilot study involving two groups of healthy subjects (mean ages 26 +/- 1.6 and 59 +/- 7.3 years, N = 7 and 5, respectively) in terms of six parameters characterizing the time-course of reactive hyperemia and their sensitivity to differentiate age effects. The reproducibility was assessed on two of the seven young healthy subjects with three repeated measurements.

Results: The physiological parameters agree with those obtained with current methods that quantify either velocity or HbO2 alone. Of the six measures of vascular reactivity, one from each group was significantly different in the two subject groups (p < 0.05)

THZ1 purchase even though the study was not powered to detect differences. The mean coefficient of variation (CV) from two subjects undergoing repeat scans were approximately 8% for the oximetric

and the arterial velocimetric parameters in the femoral vein and artery, respectively, considerably below intersubject CVs (20 and 35%, for the young and older subject groups, respectively).

Conclusion: The proposed method is able quantify multiple parameters that may lead to more detailed assessment of peripheral vascular reactivity in a single cuff paradigm rather than in separate procedures as required previously, thereby improving measurement efficiency and patient comfort.”
“In recent years, researchers have embarked on a search of computer-aided methods for diagnosis of the Alzheimer’s disease (AD) to help clinicians find more make the diagnosis earlier and more accurately such that treatment of the disease can begin sooner when there is a higher chance of success in slowing down the progression of this disease. This article presents a review of journal articles on brain signal-and image-based diagnosis of AD published in the past few years. The areas of signal processing, electroencephalogram and magnetoencephalogram are considered. In the area of image analysis, the following modalities are reviewed: magnetic resonance imaging (MRI), functional MRI, diffusion tensor MRI, and structural MRI.