Highly invasive tumors and destroy neurologically rerischen Under t Dlichsten forms of cancer seen in humans. The most widely used system for classifying and grading of gliomas is that the World Health Organization. Gliomas are graded BMS-554417 on a scale of I to IV according to the degree of the B Sartigkeit, Grade IV is the aggressive or glioblastoma multiforme. This study focused on GBM because of it. Than the brain tumor and the h Most frequent primary Re spectacular Ren adults, with the pretty highest incidence in Older people The median survival time for patients with GBM is only 9 to 15 months, and most patients die within 2 years. Although the only standard currently in use m Moderately successful treatment consists of a combination of surgery, chemotherapy and radiotherapy.
After surgery, patients are usually subjected to radiotherapy in combination with temozolomide, a DNA alkylating agent orally. Thereafter, patients still held in temozolomide treatment. While there is no real difference in the clinical benefit in patients with primary Acids or secondary Ren GBM, has an impressive improvement in the efficiency temozolomide in patients expressing a promoter methylation demonstrated methyltransferase gene methyl guanidine. It codes for an enzyme, the repair of DNA, and is reduced to be responsible for the efficient DNA alkylating temozolomide. Restrict this Restriction with inh Pensions mechanism of toxicity T connected Temozolide also means that the identification of the best, targeted molecular therapies for the treatment of GBM remains.
To be successful in getting rid of his GBM, has a number of challenges due to the location and nature of the tumor can be overcome. GBM not only locally but grow on adjacent brain tissue through the white S substance perivaskul Re and peri-ventricular Re penetrate cells and are often only a few centimeters from the primary Infiltrate rtumor. The tumor invasive nature is an essential characteristic of malignant gliomas. This results in the Unm Possibility of surgery patients gardens to h Incurred even if L versions In areas where large e m surgical resection Resembled w Re. Chemotherapy should therefore aim. Also affect tumor cells located in areas with inoperable tumors As expected to cross the blood-brain barrier to be intact in these areas requires the disease-pharmacological intervention BBB penetrating compounds.
Predict the central nervous system partitioning remains a big challenge in drug design and e w must consider a number of molecular properties During the design phase, consisting library. In vivo experimental determination of the blood-brain partition is difficult. It is long, Co Teux and are not suitable for screening large collections of chemical or he values the Durchl Permeability of compounds early in the discovery process. In vitro methods are useful, although the predictability is limited, because the models are not completely Constantly imitate the complex system dynamics in vivo. Computer models have been developed, therefore, screening of large compound libraries en resembled erm And understand the structure-activity relationships. On an objective view, the treatment success GBM disabled