Resp. In addition, after treatment with letrozole, the relative weight of the prostate complex of old rose Rennm Mice 9.7% and 7.9% and 1 and 21 days after end of treatment periods. Serum levels of the hormone stero Of are shown in Figure 1. As expected, the comparison of three different types of treatment, serum testosterone levels after 30 consecutive days of administration of the drug increased Factor Xa review Ht. One day after the dual enzyme inhibition, were h HIGHEST testosterone concentrations in the serum of gerbils adolescents, adults and old. Despite swings may need during the post-treatment, 21 days after the end of the dual enzyme inhibition, serum testosterone levels Similar as in the control of Wstenrennm Mice, young and found old au It in adults, where the concentration of hormone was lower than in the controlled group on.
Finasteride and Letrozole has entered Born a significant erh Increase in blood levels of estradiol old Rennm Mice, equivalent to more than four times the concentration in the control group, the old days after the first treatment was observed. Structural Analysis w During the duration of treatment showed an immature young control animals prostate acini consists of some still in the process of glandular modeling. The epithelium is composed of big s cells and showed signs of secretory activity of t. SMC and fibroblasts are the major compounds additionally Tzlich to the stromal collagen fibers. Prostate adult-controlled group Pr sented The morphological structure, which was fully developed and mature.
An intense secretory function of epithelial cells, which were then arranged in a pattern unique column, probably enlarged acinar light. In the stroma, fusiform SMC had formed concentric layers and wrapped tightly around the acini. Fibroblasts were removed in the epithelial base. At Older animals, the prostate by morphologically heterogeneous areas, some of which with a normal histological appearance and other histopathological characterized compromised. In areas of normal acinar secretory epithelium was functional Similar to that found in adult controls, but with small wrinkles. In the stroma, the connective tissue adjacent to the epithelial layer was slightly thicker and less compact SMC. Many morphological Ver Were changes in the compartments of prostate epithelial and stromal cells Rennm Mice adolescents, adults and old after long-term suppression of R 5a and Aro enzymes was observed.
Finasteride in the letrozole group confinement Lich of animals of all ages postnatal development, new features through the compartments of the prostate assumed much Similar to those of the exclusively Employment caused by finasteride. The first day after cessation of finasteride Finasteride and Letrozole treatment has changed the stroma Ver And rebuilt, with a remarkable accumulation of collagen in the connective tissue adjacent to the epithelial base. In the same region has been an apparent increase of the pH Notypisch VER Observed nderten fibroblasts. The smooth muscle cells have also undergone a change, as some SMC takes an irregular Owned wrinkles, thus contributing to the reorganization of the loose layer of smooth, dense collagen interspersed with several of them. W During the testing of 21 days after treatment, t