Figure 2 Open fasciotomy wound closure with extended NPWT-assisted dermatotraction in necrotizing fasciitis; A 62-year-old male patient

with necrotizing fasciitis on the left lower extremity underwent open fasciotomy on his thigh and lower leg. (A). After 7 days of thorough wound {Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|buy Anti-infection Compound Library|Anti-infection Compound Library ic50|Anti-infection Compound Library price|Anti-infection Compound Library cost|Anti-infection Compound Library solubility dmso|Anti-infection Compound Library purchase|Anti-infection Compound Library manufacturer|Anti-infection Compound Library research buy|Anti-infection Compound Library order|Anti-infection Compound Library mouse|Anti-infection Compound Library chemical structure|Anti-infection Compound Library mw|Anti-infection Compound Library molecular weight|Anti-infection Compound Library datasheet|Anti-infection Compound Library supplier|Anti-infection Compound Library in vitro|Anti-infection Compound Library cell line|Anti-infection Compound Library concentration|Anti-infection Compound Library nmr|Anti-infection Compound Library in vivo|Anti-infection Compound Library clinical trial|Anti-infection Compound Library cell assay|Anti-infection Compound Library screening|Anti-infection Compound Library high throughput|buy Antiinfection Compound Library|Antiinfection Compound Library ic50|Antiinfection Compound Library price|Antiinfection Compound Library cost|Antiinfection Compound Library solubility dmso|Antiinfection Compound Library purchase|Antiinfection Compound Library manufacturer|Antiinfection Compound Library research buy|Antiinfection Compound Library order|Antiinfection Compound Library chemical structure|Antiinfection Compound Library datasheet|Antiinfection Compound Library supplier|Antiinfection Compound Library in vitro|Antiinfection Compound Library cell line|Antiinfection Compound Library concentration|Antiinfection Compound Library clinical trial|Antiinfection Compound Library cell assay|Antiinfection Compound Library screening|Antiinfection Compound Library high throughput|Anti-infection Compound high throughput screening| debridement and preparation, extended NPWT-assisted dermatotraction was applied (B). After two cycles of treatment, the fasciotomy wounds were closed directly, and the posterior calf’s raw surface was covered with split-thickness skin graft (C). Three months after wound closure, the wounds were completely healed without complications (D). Ferroptosis assay Case 3 A 43-year-old male patient who was hepatitis B virus carrier developed necrotizing fasciitis that begun with an abscess in the left axilla. He was treated with serial surgical debridement at a local clinic for one month, but still had an open wound of 50 × 20 cm on his left trunk when he transferred to our department (Figure 3A). After thorough debridement and wound preparation for 40 days, we applied extended Temsirolimus nmr NPWT-assisted dermatotraction on his open wound. The wound had decreased prominently six days after initial application of the NPWT-assissted dermatotraction (Figure 3B). We were able to close the wound primarily without tension on 40 days of the treatment without infection (Figure 3C).

The patient was discharged without complications five days after the closure. The patient was followed up regularly at the outpatient department, and there was no complication but a widened scar at 27 months (Figure 3D). Figure 3 Open fasciotomy wound closure with extended NPWT-assisted dermatotraction in necrotizing fasciitis; A 43-year-old male patient with necrotizing fasciitis that

had developed an abscess in the left axilla underwent open fasciotomy one month before presentation. (A). After 40 days of wound preparation since initial fasciotomy, the patient underwent NPWT-assisted dermatotraction, which decreased the size of wound prominently after 6 days of treatment (B). The wound was closed directly after 40 days of NPWT assisted dermatotraction (C). The patient was followed up for 27 months and the wound was completely healed without complications (D). Discussion ADAMTS5 Necrotizing fasciitis is a rare, life-threatening condition that affects the limbs, groin, and trunk. It is a rapid, progressive infection of subcutaneous tissue and fascia that leads to thrombosis of cutaneous microcirculation and infection of soft tissues that can spread to the whole extremity in hours [11]. When diagnosis and treatment are delayed, the mortality rate can rise up to 70-100% [12–14]. As the infection progresses, tissue erythema darkens as the necrosis develops with bullae formation. Occasionally, tissue crepitus may be palpable during the course of the disease.