Magnetic resonance imaging pattern recognition studies have established characteristic radiologic
phenotypes for this disorder. In some cases, however, genetically confirmed cases do not express these features, and several reports have identified “”atypical”" radiologic findings in Alexander disease patients. Here, the authors report 3 genetically confirmed Alexander disease cases with focal central white matter lesions that, upon longitudinal clinical and radiologic evaluation, appear to reflect an atypical Alexander disease magnetic resonance imaging phenotype and not another pathophysiologic process such as encephalitis, infarction, or neoplasm.”
“Study Design. Biomechanical laboratory research.
Objective. To characterize the structural stiffness of opening and closing wedge osteotomies IPI-549 manufacturer and the independent effect of rod diameter.
Summary of Background Data. Traditionally, C7 opening wedge osteotomy (OWO) has been performed for patients with ankylosing spondylitis.
For patients without ankylosing spondylitis, closing wedge osteotomy (CWO) may be considered for more controlled closure. Biomechanical characteristics of the two osteotomy alternatives have not yet been analyzed.
Methods. Nondestructive pure moment flexion/extension (FE), lateral bending (LB), and axial rotation (AR) tests were conducted to 4.5 Nm on cadaveric specimens (C4-T3). All specimens underwent posterior bilateral screw-rod fixation with 3.5 mm and 4.5 mm Ti rods, whereas half received OWO check details and half received CWO.
Results. Independent of osteotomy type, constructs with 4.5 mm rods exhibited a significant increase in stiffness compared to 3.5 mm rods in all bending modes (P < 0.01). Relative to 3.5 mm rods, 4.5 mm constructs showed an increase in stiffness of 31 +/- 12% for FE, 37 +/- 39% for LB, and 31 +/- 11% for AR. At the osteotomy site, there was a 43 +/- 23% increase in FE stiffness,
45 +/- 36% in LB, and 41 +/- 17% in AR. Independent of rod diameter, CWO was significantly stiffer than OWO (42% for the construct and 56% across the osteotomy) in FE bending only (P < 0.05).
Conclusion. www.selleckchem.com/products/azd3965.html The surgeon can expect a similar increase in stiffness in switching from 3.5 mm to 4.5 mm rod independent of osteotomy type. The increased stiffness of CWOs has an anatomic basis. OWOs disrupt the anterior longitudinal ligament (ALL) and leave a significant anterior gap whereas CWOs create a wedge through the vertebral body and leave the ALL and the discs above and below the osteotomy intact. The closure in CWOs leaves no anterior gap providing greater axial loading stability. This greater bone on bone contact in CWOs is likely a significant reason for the anterior stiffness and may provide greater fusion rates in the nonankylosing spondylitis patient population.”
“Objective. Ameloblastomas are benign epithelial tumors of odontogenic origin, with a high recurrence rate and local aggressiveness.