“
“OBJECTIVE: To evaluate patients with wide-necked aneurysms of the posterior circulation who underwent Solitaire AB (ev3, Inc., Irvine,
CA) stent-assisted coil embolization.
METHODS: Retrospective analysis of 10 patients (age range, 32-76 years; mean age, 59.1 years) with aneurysms of the basilar artery (basilar tip, n = 5; basilar trunk, n = 4; posterior cerebral artery, n = 1). Seven of the patients presented with an acute subarachnoid hemorrhage. Five aneurysms were small, 2 were large, and 3 were giant. All patients were treated by different applications (n = 14) of the Solitaire AB neurovascular remodeling device followed by a standard coiling procedure using bioactive coils.
RESULTS: Positioning of all Solitaire AB stents was easy and successful. No stent required retrieving and repositioning after full deployment. There were no thromboembolic complications, and no dissection/rupture BMS-777607 or vasospasm occurred during stent placement. In all cases except 3, 100% lesion occlusion was observed after the initial treatment.
CONCLUSION: The initial technical and clinical results of Solitaire AB stent-assisted coiling of different types of wide-necked aneurysms in the posterior circulation are highly
encouraging, and this technique may improve the endovascular treatment of these aneurysms.”
“OBJECTIVE: Metastatic epidural spinal cord compression (MESCC) is a relatively common and debilitating complication of metastatic disease that often results in neurological deficits. Pathological fractures of the vertebral body in patients with MESCC are not uncommon. The goals of this study were to evaluate the effects Paclitaxel solubility dmso of compression fractures on long-term neurological function, as well as understand the factors that predict the development of pathological fractures for patients with MESCC.
METHODS: One
hundred sixty-two patients undergoing decompressive surgery for MESCC at an academic tertiary care institution from 1995 to 2007 were retrospectively reviewed. Multivariate proportional hazards regression analysis was used to assess the effects of pathological vertebral body fractures on ambulatory outcome, whereas multivariate logistical regression analysis was used to identify factors associated with preoperative compression fractures.
RESULTS: Sixty and 102 patients presented with and Ketanserin without pathological vertebral body fractures, respectively, and MESCC. Patients were followed for a mean of 9.7 +/- 2.6 months. The presence of preoperative compression fractures was independently associated with decreased postoperative ambulatory status (odds ratio, 2.106; 95% confidence interval, 1.123-4.355; P = 0.03). This was independent of age, preoperative ambulatory status, preoperative motor deficit, duration of preoperative symptoms, immediate postoperative motor deficit, and lytic tumor appearance. The factors strongly associated with preoperative compression fractures in this study include lack of sensory deficits (P = 0.