periodic acid schiff (PAS), Giemsa and Ziehl-Neelsen stains were negative. A diagnosis of granulomatous pigmented purpuric dermatosis was made. From the 10 cases reported of this granulomatous variant, 6 were associated with hyperlipidemia. We report an additional case with this association.”
“Recent clinical studies indicate that blockade of the renin-angiotensin system is important to prevent stroke, and accumulating results of basic research also
indicate the possible involvement of the central renin-angiotensin system in ischaemic brain damage and cognition. CP-868596 inhibitor When the angiotensin II type 1 receptor is blocked by an angiotensin type 1 receptor blocker, unbound angiotensin II acts preferentially on the angiotensin II type 2 (AT(2)) receptor. These results suggest the pathophysiological importance of the AT(2) receptor in the clinical use of angiotensin type 1 receptor blockers, which are widely used in patients with hypertension with the expectation of a decrease in the onset of cardiovascular and cerebrovascular disease. We review here the possible
roles of AT(2) receptor activation in the brain, focusing on ischaemic stroke, cognitive function and neurogenesis, and potential effects of specific AT(2) receptor agonists.”
“Invasive aspergillosis is a life-threatening condition in patients with chronic granulomatous disease (CGD). Skin invasion by Aspergillus occurs most commonly by contiguity to a neighboring cavity. PXD101 We describe an unusual selleck inhibitor case of invasive cutaneous aspergillosis presented as a large burgeoning tumor in a 4-year-old girl with CGD who underwent surgical treatment for bifocal osteomyelitis of the left leg. The skin invasion occurred 4 months after a “”successful”" treatment of invasive pulmonary aspergillosis. Atypical presentation and diagnostic difficulties are discussed.
Invasive cutaneous aspergillosis may be polymorphic. The diagnosis should be considered early in the etiological investigation of any suspicious skin lesions in CGD even in uncommon aspects such as burgeoning tumors.”
“The angiotensin AT(2) receptor (AT(2)R) represents an important component of the renin-angiotensin system since it is involved in the (patho)physiology of different cardiovascular and neuronal diseases. Furthermore, AT(2) receptors can partly mediate beneficial effects of angiotensin AT(1) receptor (AT(1)R) blockers, and direct pharmacological AT(2) receptor agonism emerges as a novel therapeutic strategy. This review discusses the constitutive and ligand-mediated activity as well as the signal transduction of the AT(2) receptor, focusing on adapter proteins which directly bind to this receptor. Direct protein-protein interaction partners of the AT(2) receptor described so far include the transcription factor promyelocytic zinc finger protein, AT(2) receptor binding protein and the AT(1) receptor.