pylori might not appear to play an important role in severity of PUB. Idiopathic (H. pylori-negative, drug-negative) PUB had a strong tendency of re-bleeding after initial hemostasis. Key Word(s): 1. peptic ulcer; 2. gastrointestinal bleeding; 3. Helicobacter pylori; 4. non-steroidal anti-inflammatory drug Presenting Author: TAKEHIRO MIYAZAKI Additional Authors: KAZUYA AKAHOSHI, HIDENOBU KOGA, AKI MIYAGAKI, MASARU KUBOKAWA, YASUAKI MOTOMURA, JYUNYA GIBO, NOBUKATU KINOSHITA, SHIGEJI OSADA, YUZOU SHIMOKAWA,

KAYO TOKUMARU, YOSHIHIRO OTUKA, TAIZOU HOSOKAWA, NARU TOMOEDA, RAN UTUNOMIYA, KAZUAKI MIYAMOTO Corresponding Author: TAKEHIRO MIYAZAKI Affiliations: Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Iizuka Hospital,

Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Iizuka Hospital, Dabrafenib research buy Iizuka Hospital Objective: Upper gastrointestinal bleeding (UGIB) is a common cause of hospital admission and morbidity and mortality are still high despite advancements in endoscopic and acid suppressive therapy. Kinase Inhibitor Library supplier The requirement for first year Gastrointestinal (GI) fellows to start urgent endoscopic therapy is, however, still controversial. The aim of this study is to compare the clinical outcome between first year GI fellows and attending doctors on the endoscopic treatment of UGIB alone in the emergency department. Methods: Between April 2008 and March 2013, urgent endoscopy was performed for 442 consecutive patients (288 male and 154 上海皓元医药股份有限公司 female; mean age, 73 years), presenting symptoms and signs of UGIB, in the emergency department at night. 227 patients

who underwent endoscopic hemostatic treatment were enrolled in this study. 57 patients were treated by first year GI fellows (8 endoscopists) whose endoscopic training period was from 6 months to 12 months (Group A) and 170 patients treated by attending doctors (21 endoscopists) whose endoscopic training period was more than 1 year (Group B). In these two grade endoscopists, initial hemostasis, mortality, re-bleeding and need for interventional radiology (IVR) rate were retrospectively compared using medical records. Results: Initial hemostasis was obtained in 57 out of 60 patients treated by Group A (95%) as well as in 162 out of 170 patients treated by Group B (95.3%). Re-bleeding occurred in 5 cases (5.2%) treated by Group A and 11 cases (4.7%) treated by Group B , but this difference was not statistically significant (p > 0.05) Also, the differences between the two groups of patients in the need for interventional radiology (IVR) and mortality were not statistically significant (p > 0.05). Conclusion: First year GI fellows with endoscopic training of six months may be able to perform urgent UGIB treatment effectively and safely. Further extensive prospective control studies are needed to clarify this point. Key Word(s): 1.