Chromatin remodeling histone see k Can through a series of fa Ons, such as acetylation, methylation, phosphorylation, ubiquitination and sumoylation can be modified. Histone acetylation occurs at lysine residues and is catalyzed by histone acetyltransferases, is associated with the activation of gene transcription, w During histone deacetylation catalyzed by deacetylases, is associated with the silence gene transcription. HATS and HDACs are acetylation or deacetylation not only of chromatin proteins, which can lead to a revised regulation of gene transcription, but also to histone proteins Controlled Lant the cell cycle progression, differentiation and / or apoptosis. Inhibitors of these classes of proteins have, particularly HDACs are promising anticancer agents mainly because of their cell cycle inhibition and induction of apoptosis was examined. Recent literature has shown that epigenetic Ver Regulate changes in genes that regulate cell growth, apoptosis and cell cycle are also involved in the development of drug resistance. Govern epigenetic profile, the response of individual therapy and skills of these Ver Changes in the fight against problems such as the impact of resistance on the heart or tee important. In a recent study, the treatment of cancer cells with an HDAC inhibitor, trichostatin A. preassembled Registered Born in fa Constant radiosensitization of all tested cell lines was also observed that TSA-induced Rivaroxaban Factor Xa inhibitor radiosensitization was clear from the p53 status and ATM cells affected. HDACs play an R Crucial role in the recognition and repair of DNA-Sch To. In addition, it was reported that the interaction between radiation and ATM HDAC obtained Ht. In addition, it has been shown that HDAC4 withgH2A.X defendant shops DNA in irradiated cells colocalized, suggesting that HDAC is the detection of DNA Sch deterioration or gH2A.X mediation mechanism involved in DNA repair. HDAC inhibition was also observed to be reduced to a level of angiopo Retina, HIF-1 alpha, VEGF, COX-2, etc.
But will this effect is not mediated by an epigenetic modification, because that would lead to an increase in acetylation of their Tr Happy that the activity T erh ht. Therefore, there is a strong need to explore further the causes and mechanisms of HDAC inhibitors in the fight against radioresistance. Therefore, k Nnte targeting epigenetic regulators as a new approach to achieve radiosensitization be examined for cancer cells. 5th Ionizing radiation in the treatment of cancer and its secondary Re phytochemicals Zoledronate with chemotherapeutic modulation The goal of the fight against cancer is to reduce the incidence of the disease, reducing morbidity t and mortality T and a better quality t to weight hrleisten lives through early detection, treatment, rehabilitation and palliative care. This k Nnte be achieved only if there are prior knowledge about the mechanism, and the fully understand the disease processes. The three most popular treatments for cancer closing S surgery, chemotherapy and radiotherapy. Each of them are from their own set of Restrict Website will because of factors Including, Lich, location, size E, stage of cancer, limited to the age and health of the patient. Surgery is the best option if the tumor is localized, but in an advanced stage, this option is no longer viable. Chemotherapy and radiotherapy.