The majority of pathological diagnoses are rarely used by biopsy in Korea, China and Hong Kong, with fine-needle INNO-406 aspiration. In contrast, 30 or less pathological diagnosis by biopsy in Japan and Taiwan. Taiwan dam Ftigt FNA cases in about 10 F But uses a surgery for pathologic diagnosis in about 38 F Cases. Protocols known as biopsy-proven HCC registration w Re inconsistent with current practices in Japan and Taiwan. The Committee agreed that the trials in the metastatic setting advanced histological Best Confirmation of HCC is not required. In addition, pretreatment biopsy was dinner tumor seeding, which would complicate the neoadjuvant studies. Staging a variety of classification systems are used worldwide.
Many of these systems are based on the paradigm of tumor metastasis or TNM groupings incorporate calculated as a variable. Other systems, such as the system of clinical staging of liver cancer Barcelona also took Ma Liver function and underlying disease. To complicate the international Trichostatin A design of the clinical study, the variable use of these systems in Asia and the world. Each region of Asia represented by the jury currently uses a different system. In China, the revised criteria for staging is prim Rem liver cancer used. This system was developed by the Chinese Society of Liver Cancer. The system uses the criteria of size S, number and location of tumors, lymph node spread, extrahepatic metastasis, portal vein and liver function is based. In Japan, both the classification system and the implementation of the algorithm for the treatment of hepatic function as the first category of the evaluation pleased t that the size S tumors.
Hong Kong does not have a unified classification system. W While BCLC is considered a valuable tool for a treatment algorithm in Hong Kong, the system will be less useful for forecasting. The prognostic index of Chinese universities T was useful for predicting at least one center because of the Bev POPULATION most advanced. Korea uses a modified version of the International Union Against Cancer and Taiwan used BCLC system. TNM classification systems based one big disadvantage of these systems, he ignored the underlying liver disease. In HCC, the presence of liver disease is an important prognostic factor and common component determining treatment. For these reasons, the TNM-based systems have limited value in the overall management of HCC.
The Child-Pugh score is a widely accepted system for assessing liver function. Despite empirical selection of variables, this tool is a simple bed, the mortality t In patients with cirrhosis and a degree of accuracy is not much less than the statistically robust model for liver disease in the terminal phase predicts. BCLC classification includes Ma Took the liver function and has become the standard for the design of clinical trials. However, this system is not typically used in East Asia, with the exception of Taiwan. China-specific,