Participants were recruited

from one of five locations at which they were receiving treatment: three community practices, and rehabilitation day treatment in a nursing home and hospital. All were outpatients. Randomisation for all sites was conducted by an independent third party who was blinded to the potential participant’s characteristics. The randomisation schedule consisted of a random allocation list for each site. Each list had block sizes of four (Altman et al 2001). No other stratification took place. After baseline measurement, the therapists were notified to which group the participant was assigned. The participants were not blinded to the treatment they were allocated because they were aware PI3K inhibitor of the content of the treatment they received. Therapists were not blinded because they taught the participant the imagery or relaxation techniques. People entering the trial had to meet the following inclusion criteria: clinically diagnosed www.selleckchem.com/products/Perifosine.html adults with Parkinson’s disease, and sufficient cognitive level and communication skills to engage in mental practice. The latter was determined by taking into account the clinical judgment of the treating therapist, support from family and the score on the Mini-Mental State Examination (Tombaugh and McIntyre 1992). Patients who had other

conditions such as stroke, rheumatic diseases, or dementia prior to the onset of Parkinson’s disease and sufficient to cause persistent premorbid disability were excluded. At baseline, the following participant characteristics were recorded: age, gender, time since diagnosis of Parkinson’s disease, cognitive level assessed with the Mini-Mental State Examination (Tombaugh and McIntyre 1992), Hoehn and Yahr stage (Hoehn and Yahr 1967), and the use of walking aids. The participants recruited were already receiving physiotherapy according to the Dutch guidelines for patients with Parkinson’s disease (Keus et al 2004), some on a one-to-one basis and some in groups. This pre-existing treatment was continued. The randomly allocated ‘new’ treatment was

incorporated into the participant’s program. All participants received six weeks of physiotherapy, leaving science their own therapy frequency and organisation unchanged. Participants received either one hour of physiotherapy per week (groups) or two sessions of half an hour per week (individuals). Thus, in both cases, participants continued to receive six hours and did not increase their contact time with the therapist. If participants were treated on an individual basis for half an hour, 10 minutes were spent on mental practice or relaxation. In group sessions of one hour, the time was increased to 20 minutes. Therapy with the therapist was recorded in pre-structured files, which detailed content and duration.