Unilateral oophorectomy implies a significant reduction of the ovarian follicular reserve. Thus, one might expect that the time to menopause is shortened by several years in women who have
undergone unilateral oophorectomy. A retrospective cohort study of 23 580 Norwegian women who were included in the population-based HUNT2 Survey during the years 19951997. Data were obtained by two self-administered questionnaires at study inclusion. Cox proportional hazard models were used to estimate p38 MAPK cancer relative risks of menopause according to unilateral oophorectomy status with and without adjustment for birth cohort, parity, smoking, body mass index (BMI) and age at menarche. Women who had undergone unilateral oophorectomy were younger at
menopause [mean 49.6 years; 95 confidence interval (CI): 49.250.0] than women without unilateral oophorectomy (mean 50.7 years; 95 CI: 50.650.8) (P 0.001). The crude relative risk of menopause was 1.28 (95 CI: 1.151.42) and remained similar after adjustment for the study factors above (adjusted relative risk 1.27; 95 CI: 1.141.41). In addition, recent birth cohort and high BMI were associated with higher age at menopause. Information on unilateral oophorectomy was based on self-reports. Some women may therefore have been misclassified. Although the effect of unilateral oophorectomy on the age at menopause is similar to that of smoking, it is weaker 17DMAG than anticipated from the loss of ovarian follicular reserve. Thus, compensatory mechanisms may occur in the remaining ovary. The present study was supported by the South East Health Region Norway (grant no. 2739100). None of the authors has a conflict
of interest.”
“Background: Canadians of Chinese descent, represent one of the fastest growing visible minority groups in Canada, (as well as the second largest), but relatively little is known about the clinical features of heart failure (HF) in Chinese-Canadian versus non-Chinese Canadian patients. Methods: We conducted a population-based analysis of urban patients hospitalized in Ontario, Canada for the first time with a most responsible diagnosis of HF between April 1, 1995 and March 31, 2008. Among the 99,278 patients, 1,339 (1.3%) were classified as Chinese using a previously EPZ5676 validated list of Chinese surnames. Through linkage to other administrative databases, we compared the clinical characteristics, pharmacological management, and outcomes of Chinese versus non-Chinese HF patients. Results: Ischemic heart disease was identified as the possible etiology of HF in a greater proportion of non-Chinese patients (47.7% vs. 35.3%; p smaller than 0.001) whereas hypertension (26.1% vs. 16.1%; p smaller than 0.001) and valvular heart disease (11.6% vs. 7.2%; p smaller than 0.001) were relatively more common in Chinese patients. Chinese patients were prescribed angiotensin-converting enzyme (ACE) inhibitors less frequently (57.5% vs. 66.4%, p smaller than 0.