The best train for the south Acid, the pH-POA itself, which is not absorbed by the intestine. POA inhalation as Erg nzung given to PZA Oral h tte following benefits: You would the size e of the bacterial population of PZA orally and the duration of the period of the T least, get tet to hen increased because the fragment active and would probably not be the first cause 3-Methyladenine 3-MA of Lebertoxizit going t be, it w re a reduction of the oral dose PZA Hepatotoxizit t erm too aligned and thus for almost all the resistance mutations were found in the pncA gene, encoding the deamination original, k they nnte bactericidal activity of t, even in the presence of PZA resistance. A combination of oral treatment with a high dose of rifamycins, oral PZA, hopefully, TMC diarylquinolone and inhalation therapy assistant POA M for may have can k A huge reduction in the duration to make the treatment of tuberculosis.
We pulmonary think it is realistic to expect that such a combination of drugs k Nnte the duration of treatment in a single month reduced. Chrysin 480-40-0 . Pulmonary delivery of anti-tuberculosis drugs delivery of targeted therapies against tuberculosis infected lungs directly results in immediate contact with the drug TB bacteria, which leads to high doses of local drug and the rapid onset of the T Th stock. The lung has a big s surface And surface adsorption of a thin alveolar epithelium. H Here lung bioavailability and rapid absorption of the drug through the lung epithelium erm Adjusted lower doses of drugs, while maintaining an effective systemic concentration.
Should have a lower dose with the absence of first pass metabolism and the prevention of gastrointestinal dinner combined input possibility, a reduction of systemic side effects and improved reps. A number of anti-TB drugs have been in dry microparticles for pulmonary delivery, including normal capreomycin and para-Aminosalicyls Acid has been formulated. Pimobendan The results showed that the direct supply leads to the lungs indeed to high local concentrations and reduced bacterial load in the same treatment by other means made available, providing the M Possibility, h get Higher doses and fewer systemic side effects . TB drugs have been also formulated in nanoparticles for pulmonary delivery by a number of researchers.
e encapsulation of drugs in nanoparticles, the M Opportunity, stability t, and better protection of the molecule of interest, drug action and delayed Siege to release , improving the bioavailability of poorly l soluble therapeutic and drug targeting to specific organs, cells or receptors. It also allows the small size E of the nanoparticles to escape them two mechanisms and phagocytic mukozili Re clearance in the lungs and Pandey al. administered rifampicin, isoniazid and pyrazinamide encapsulated in biodegradable polylactide co-glycolide nanoparticles in the lungs of guinea pigs with nebulization. They showed that the aerosol formulation to maintain therapeutic concentrations in the lungs until today. In an improved drug formulations, PLG, Sharma et al. Surface Surface functionalized nanoparticles with wheat germ agglutinin, a lectin withbioadhesive properties, which also sustained levels of drug in the lungs of guinea pigs to this day. Zahoor et al. shown that alginate nanoparticles encapsulating rifampic

Eting spectral information in the S and P. sp Ter were technological developments and design of complex pulse sequences and access to bonds connectivities R t information Umlichen spin systems, so that NMR spectroscopy to be used more on an absolute basis. However, in these decades has been the continuous development of comparative NMR and PED. Spectral databases were built, and now there are many CEP-18770 commercially Ltlichen boards databases with information on key spec, the chemical units, including many bisindoles. These databases are in most cases Cases in connection with Chem modules chemical shift prediction Including Lich H, C-and N-cores chemicals. With the development and improvement of the various algorithms behind these predictors Pr, Now they serveas a fast and reliably SSIGE sources of information, which helps considerably in their SPECTRO scopists Strukturaufkl Tion.
With the development of pulse sequences and new methods of processing new to big there is interest in recent years, such as covariance, covariance and indirect covariance NMR indirect unbalanced cal application processing indirect covariance NMR, set as a series of HSQC-TOCSY data results in HH connectivities t information in the frequency domain C, we get a CC-TOCSY spectrum. Indi rect with asymmetric covariance NMR processing, it is m Possible to combine mathematical observed D NMR data to calculate it Equivalent of a data-sensitivity significantly lower correlation NMR. The application of this method to obtain from the HC-HSQC and HMBC spectra HN CN data correlation has been demonstrated for VLB as a model system.
None of these treatments is creating new con-connectivities t information that is not already in the spectra of which date them, but they provide a more fa We win connectivities t information. The use of these potentially useful correlation data would Strukturaufkl Tion computer. CAS systems have recently reached a stage of development, so that they can greatly facilitate the Aufkl Tion of structure structure structure complex alkaloids. Although these developments are not the point at which the gel unknown structures without human intervention St k be achieved Nnten, they are a useful source of structural gene to propositional.
In addition, and as a development that increasingly have an impact in the foreseeable future, the recent introduction of production Ngern NMR spectrometers with multiple receivers, And the use of sp Rlicher vegetation sampling data, allows spectra of several different nuclear species should be recorded in parallel, and a plurality of standard pulse sequences are combined in a single unit. This should further reduce the measurement time of the correlation experiments, the Aufkl Tion simplifies the structure of the active bisindoles. . Conclusions In the first part of this summary, we have shown that the determination of the structure of derivatives such as bis-indole may be new synthetic derivatives, impurities or metabolites, mass spectrometry used in practice elemental composition are for determining high res Send measurements and the location of the altar ation compared to the starting material or of a parent compound. To achieve this, a detailed analysis

Driving time from rocuronium can be used the principle of synchronization, which does not affect the appearance of the time of rocuronium, but induces muscle relaxation, and how pleased t the same anesthesia. But RIP one hour INDICATIVE, painful and severe pain makes the patient piq Re s arm, especially HIF-1 Alpha when rocuronium before unconsciousness was injected Although the pathophysiology of this pain is not yet clear, it may be d activation of nociceptors by osmolality t or pH value of L solution or activation of endogenous histaminekininlike withdrawal movements of inflammatory mediators by rocuronium can adversely affect the patient. Because of the pain and emotional stress may need during the anesthetic, are k Can bronchospasm, asthma, or myocardial infarction induced.
Pretreatment or mixing with a variety of drugs such as opioid Of the lidoca Parts, midazolam, esmolol, thiopental, metoclopramide, baking, ondansetron, or tramadol techniques such as dilution with NaCl. were before, studies in which the lidoca know, found esmolol, bicarbonate, or dilute with drugs A-966492 PARP inhibitor effective in reducing NaCl.were RIP. The lidoca Is the agent most studied and has been very effective in reducing RIP In this study, we have decided that the effect of ephedrine, the rate has not been studied previously, and compare it with the lidoca . do Ephedrine has no analgesic effect. But some m Possible mechanisms have been suggested to induce analgesia. Bradykinin has been reported that mesenteric norepinephrine efflux from sympathetic nerves innervating ends canine pulmonary arteries and inhibit, it was suggested that endogenous noradrenaline released by ephedrine may reduce the effect of bradykinin.
Also TekoL al.reported and improving analgesic effects of opioids Of ephedrine, both experimentally and clinically. , The alpha-adrenergic stimulant effects of ephedra played a R In the intervention group. It has been shown that spinal administration of norepinephrine or produced analgesia in humans and experimental animals. It is postulated that the pain associated with propofol and rocuronium is similar: It seems t immediately after the administration, its short duration and the intensity increases with t following injection. The effect of ephedrine on propofol injection pain was investigated and reported different results. Pretreatment ephedrine has been shown to effectively whichmg in a study by Austin and Parkein TomL ofpropofol ephedrine was used.
In the study by Cheong and pretreatment Aland g kg ephedrine was effective against the pain of propofol injection. However, ephedrine has been reported that at preventing pain during injection of the GCA of propofol in the study Ozkocak et al ineffective in our study, we have decided ephedrine at a dose of GCS, which proved effective against the pain of propofol injection, since no significant adverse h thermodynamic. Like in previous studies, we observed RIP inch of our patients without prior treatment. In our study, the lidoca Was found more effective than ephedrine to relieve RIP Similar to studies by Cheong and al.and Memis and Wongin that rocuronium was also used by the principle of synchronization. RIP is at the patient when the ephedrine pretreatment was applied prevented. Although this percentage was not as high as the lidoca Have pretreatm

Lead to the determination of risk assessment for TB, however, new laboratory tests, such as IGRA studies and for screening donor effectively validated. Although SOT-receiver Be regarded singer, an hour Have higher risk for tuberculosis, have defined only a few clear risk factors. Among the risk factors that have been described, age, non-renal Transplantatabsto Are Syk Signaling Pathway UNG, and the type of immunosuppressive therapy such as OKT-Antique Rpern and T-cell-depleting positive TST, radiographic evidence of previous tuberculosis, is an H hemodialysis is not for L Ngere time, infection with hepatitis C chronic liver disease and other coexisting infections such as fungal infections, cytomegalovirus, Pneumocystis carinii, Nocardia or treated. However, most previous data were either from a kidney transplant or report on clinical experience and descriptive studies.
In a recent prospective cohort study from Spain, the age and receiving a lung transplant have been Lacosamide identified as risk factors ungsreaktionen w During pre-transplant chronic lung, liver or kidney disease, diabetes repulsion, And not the type of immunosuppression appears to hen the risk of tuberculosis increased. In our study, a di t tacrolimuscontaining and considered CMV infection in prior months leading risk factors for tuberculosis. Our results differ materially from historical studies that show no association of tacrolimus with tuberculosis. One explanation Tion for this is that the design studies and comparative analyzes were different. In theprevious studies, there was a prospective cohort study, the other a retrospective case-control.
However, there have been few descriptions of the association of tacrolimus with the infection. Tacrolimus module has two cellmediated and humoral immune responses, particularly by the activity Of calcineurin and subsequent t End production of interleukin and istimes effective than cyclosporine in their immunosuppressive effect. So it may have inhibitory effects on cyclosporine lower than T-cell immune function, which is an important defense mechanism against tuberculosis. In a systematic review of TB in SOT-receiver singer, tacrolimus with early-onset transplant within months of tuberculosis compared with azathioprine or cyclosporine alone was associated P.. Tacrolimuscontaining regime seems to be the increased risk of P. Hen jirovecii in renal transplant patients.
However, a meta-analysis showed that compared to cyclosporine after heart transplantation, tacrolimus was no significant difference in infections between tacrolimus and cyclosporine relative risk CI, p. Calcineurin inhibitors have also been reported to agentsin the risk of invasive fungal infections such as Cryptococcus and zygomycetes to reduce the, and interact synergistically with antifungal agents SOT receiver singer. Despite these controversial data regarding the effect of tacrolimus on infection, the results of this study indicate that tacrolimus is a significant risk factor for tuberculosis, especially in view of the pathogenesis of tuberculosis and a high activity t immunosuppressant tacrolimus. We also observed that previous CMV infection was h More common in TB patients. CMV infection in the tr Gt to the deterioration of T cellmediated immunity t, often in front of a superinfection with other opportunistic infections such as pneumonia. However, we could not

H following administration. These results suggest that to achieve the combination of prostaglandin analogues with ketorolac after initiation of treatment, a st Rkere IOP-lowering effect as original new approach to treating patients with glaucoma may be recommended. However, the long-term topical use of NSAIDs with serious adverse effects on the Augenoberfl Connected surface and Everolimus mTOR inhibitor cause k Can unexpected effects on IOP. Therefore, patients should closely w Be monitored during widespread co-treatment with these agents far, and this combination should be limited to a short period of time. Uveoscleral outflow decrease was found in the pseudo-exfoliation syndrome. In the travoprost group, all patients had POAG, and this agent is a st Rkere affinity t-selective receptor, although these patients had h Here travoprost IOP values during withdrawal for reasons that are unclear.
Cited in all other studies, only with latanoprost no meaningful application E7080 VEGFR inhibitor Ftigen results was investigated. To our knowledge our study is the first to evaluate the effect of NSAID use of bimatoprost and travoprost. The short duration of the study was based on the fact that NSAIDs with toxic effects eye long-term and long-term NSAID use is rare in practice can be justified Ophthalmology k, Be related decision. The Website will RESTRICTIONS Our study are the small Stichprobengr E, and the inclusion of patients without POAG. In addition, k Concomitant use of NSAIDs at the start of treatment with PG analogues clearer information about the interactions between nnte these two drugs.
We believe that the short duration of the study is not a big e RESTRICTIONS LIMITATION, and we do not expect to axitinib significantly different results for the long term. However, our results have in gr Best eren studies Saturated with patients from different ethnic groups with a sufficient number of both sexes. As a result, the simultaneous administration of topical ketorolac with three different PG analogues in patients with glaucoma has been entered Born in potentiating the effect of IOP-lowering PG analogues. However, few studies, the various anti-glaucoma, and most previous studies on anti-glaucoma drugs, clinical trials, the Augenoberfl Surface compared to only evaluated by impression cytology. To the best of our knowledge there are no studies comparing the effects on the Augenoberfl Surface of the fixed combination glaucoma medications and the simultaneous administration of two drugs, the fixed combination of drugs.
We investigated these effects and the mechanism of evolution of Augenoberfl Surface to determine whether the different classes of anti-glaucoma, the H FREQUENCY Of drug use or effect of preservatives in the gr Th drugs had impact on the net Changes Augenoberfl the surface using the conjunctival impression cytology studies and conjunctival biopsy specimens in rabbit eyes. Materials and Methods Animals Twenty-four meters Nnliche were white E rabbits weighing between 2 and 2.5 kg New Zealand used for this study. The rabbits were placed under Quarant Ne and acclimatized one week prior to the experiments using laboratory animals in St. Mary H Pital, Catholic University of Korea. The experiments were performed on rabbits under normal conditions w carried out during the entire study, as follows: room temperature

Or bacteriological analyzes. A total of 41 diseased fish were collected, including 10 3 of farm 1, farm 2 6, and 25 of P450 Inhibitors the farm 2.2. Isolation and biochemical characterization For bacterial isolation, samples of brain, kidney, liver, and ascites fluid from diseased fish sampled for fa Aseptic is distributed on a sheep blood agar, and at 25 8C for 72 h Pure colonies were a Gramf Staining, catalase and oxidase tests for the presence of H Thermolysis and growth at different temperatures and on MacConkey agar. The St Strains were at 80 8C in brain heart broth held at 15% glycerol until use. Before the biochemical and molecular tests, the isolates were cultured on Rogosa & Sharpe agar at 25 8C man for 24 h. Biochemical characterization was performed using the Rapid ID32 Strep commercial kit. 2.
3. Molecular analysis of the amplification and phylogenetic tree construction and sequential Age of 16S rRNA gene were for nine Feeder Llig selected Hlten Isolates from the total number of isolates performed. Total DNA was prepared using the commercial kit DNeasy. 16S rRNA was amplified by PCR with primers verst for the universal C70 and B37 Are RKT, as described by Fox et al. The PCR products were purified using a Wizard PCR Preps kit and sequenced using preheating Rts and Rev Rts primers. The sequential reactions Ages were recorded with a terminator cycle sequencing kit BigDyeTM Age and run on an ABI 3730xl Genetic Analyzer. The sequences were then compared to sequences in the NCBI database using BLAST algorithm. The limit for the identification of a bacterial species was 98% identity t of the nucleotides of the 16S rRNA gene.
The phylogenetic relatedness of the isolates was determined by comparison of 16S rRNA sequence analysis of the gene. The sequences of the isolates were aligned with ClustalW with BioEdit sequence of the following bacterial species: Weissella paramesenteroides NRIC 1542, Weissella thailandensis FS61 1, 2973 NCFB hellenica Weissella, Weissella confusa JCM1093, Weissella cibaria LMG 17 699, NRIC 1536 viridensces Weissella, Weissella minor, NRIC 1625, 1627 NRIC halotolerans Weissella, Weissella kandleri NCFB 2753, S 5623 koreensis Weissella, Weissella soli LMG 20 113, LMG 25373T beninensis Weissella, Weissella ghanensis LMG 24 286, 257T fabaria Weissella, Pediococcus, and Weissella sp damnosus strain fish. JZ 1L.
The genetic distance matrix was performed using the Kimura two parameter models, and an evolution Rer tree was with the neighbor joining method MEGA4. Bootstrap values of 1000 are replicated as percentages. Weissella genus-specific PCR was performed for all isolates using the primers and Weir Welf folllowing Jang et al. with some modifications. Briefly, the amplification with a denaturing cycle at 95 8C for 5 min by 30 cycles of 95 8C series for 30 s, 55 8C for 45 s and carried out for 72 8C for 1 min in advance, min with a final extension 7 at 72 8C. 2.4. Antimicrobial susceptibility testing of pathogen resistance to five hours Ufigsten has used antibiotics in aquaculture has been identified globally for all isolates using the disk diffusion tests. The tests were carried out in accordance with M42-A guidelines recommended by all Changes to the bacteria streptococcus. Hard drives with the antimicrobi

T clinical centers treat at home Benazepril  RAAS inhibitor varies from almost zero to about 50%. Two randomized patients with acute PE and a low risk for complications receive either LMWH h Capital for only 3 days vs hours altogether Pital 256 or all of the h Pital round at least in part to the h Pital 257th This l sst It closes S that the appropriate treatment of patients with acute PE selected Hlt increased not at home ht recurrent VTE, bleeding, or mortality t. There are a number of rules for the prediction to identify patients with acute pulmonary embolism with a low risk of serious complications and can k adapted for the treatment at home. 258 263 of these, the PE severity index is the best validated 261 262 264 266 and was used to identified patients for home treatment in most clinical trials before w Select. Patients with acute illnesses S PE, which appear to meet the following criteria appropriate for the treatment of H hospital Clinically stable, with a good supply of heart-257, a good social support with easy access to medical care and supervision should be the same.
The patient must also feel good enough to be treated at home. accordance with the fi ndings of these two trials, a systematic check of 11 observational studies 267 and four recent observational studies have reported a very low H FREQUENCY low risk of complications in patients with acute PE were first how to output all or partially treated at home. About one-third to the H Half of outpatients with acute pulmonary embolism appears to be low risk in this group. 272 The evidence from randomized trials is of average quality T, fi ndings support other observational studies. Recommendation 5.5. In patients with low-risk PE circumstances and the house ends Inappropriate, we recommend an early release may need during the discharge standard. Notes: Patients who prefer the security of the h Pital the convenience and comfort of your home are probably the hospital w Choose during the treatment at home w. 5.6 Systemic thrombolytic therapy for PE 5.6.1 systemic thrombolysis vs anticoagulation alone for EP: Randomized studies have found that, after 24 hours, thrombolytic therapy, pulmonary arteriovenous h thermodynamic measurements of the arteries, oxygen se, improves circulation Lung and echocardiography. 273 thrombolytic therapy, however, does not appear to Ausma it to reduce the residual thrombosis.
It is uncertain whether the receiver singer faster Aufl Solution obtained from PE The risk of bleeding with thrombolytic ht, predominate. In patients with PE, the severity of the presentation on the extent of the embolism and the presence and severity of chronic heart-lung adversely caning from. 104 274 275 patients with the severest Pr Presentations to the h HIGHEST risk, have an acute illness PE, most of thrombolysis to win. Prognosis of patients with acute pulmonary embolism Among patients who were diagnosed with PE and early treatment will die 5% of the original EP or another EP in the n Chsten 7 days. 9104276 279 However, although the risk Etoposide SRC inhibitor of dying of PE differs from the F Is indicated in patients, is not a tool pr Diktiven validatedrisk available. The risk of dying of PE business at 70% Is protected when cardiac arrest occurs, 30% if a shock is required inotropic support, and 2% in patients not hypotensive. 104 276 278 280 281.

The study was considered negative because it Clofarabine Clolar is not their prime Endpoint of objective response rate according to Ren RECIST. These data are in contrast to a phase II trial of another mTOR inhibitor everolimus, used in combination with 5 or 10 mg 30 mg of octreotide. The study showed that 22% of patients had a partial response and 70% had stable disease. The promising phase II everolimus led to two randomized Phase III. RADIANT 2 was a randomized trial evaluating everolimus 10 mg of t Resembled versus placebo in 429 patients with malignant carcinoid Progressive functionability compatibility available. The median progression-free survival was 16.4 months to 11.3 months compared to arm in arm everolimus plus best supportive care. However, the PFS is not their prime Ren endpoint PFS conferred on central radiology and the difference was not statistically different basis are fulfilled. RADIANT 3 was, but clearly. This study was a Phase III study of everolimus 10 mg / day plus best supportive care alone in 410 patients with progressive panNETs.
This study showed a significant improvement of 2.4 times the median progression-free survival time. Side effects associated with everolimus consisted of stomatitis, rash, diarrhea, fatigue, infection and Pr Prevalence of upper respiratory tract. As mentioned sunitinib trial Above, it is not clear that the duration of each of these toxicity Th is important that patients requiring chronic treatment. The h Ufigsten grade 3 or 4 drug-related adverse events were stomatitis, An Chemistry and hyperglycemia Chemistry. The above data show clear clinical antitumor activity t of sunitinib, and everolimus, however, it is important to Recogn However, that patients enrolled in these studies had progressive disease. Patients with advanced NET have h Frequently indolent disease and may expectantly at times for months or even years to be followed without treatment. A sorgf insurance valid for evaluation of each patient with a anf Nglichen interval of observation and analysis of k You can find out who needs more treatment, tt is likely to do against the well without treatment over a liter Extended period is. It is important to remember that all therapies and interventions involve risks and side effects. The adverse event profile of sunitinib, and everolimus are predictable, but can The quality of life T adversely Mighty and should be considered.
As mentioned above HNT are carcinoid tumors And the other networks found Rich tumors, the h Expressed frequently and VEGF. Bevacizumab has been randomized in a phase II study in 44 patients with advanced or metastatic NET to receive either pegylated IFN 2b or bevacizumab tested. There was a partial response rate of 18% in the bevacizumab group, compared to 0% in the IFN 2b. At the age of 18 weeks were 96% of patients treated with bevacizumab progression-free compared to 68% of patients treated with IFN 2b. Hypertension grade 3 or 4 at 53%, markedly Higher than the 21%, 11 in the c Pivot-lon, lung and breast cancer studies has been established to report, but easy to control It with antihypertensive drugs. It should be noted that 40% of patients in the bevacizumab has no documentation of progression of the disease at the start of the study. A Phase III trial of bevacizumaboctreotide against IFNoctreotide is currently underway. Radiolabeled somatostatin analogue therapy.

N of the calcium channel androgen receptor antagonists patent blocker, verapamil, the ben To do prior can not produce a reversal in vitro MDR-TB can be obtained in patients with Kardiotoxizit Th important. Valspodar biricodar and showed a significant pharmacokinetic interactions with paclitaxel1, 3, 10, 11 Add biricodar to doxorubicin and vincristine treatment did not significantly increased Hen the antitumor activity of t or survival12. Previously, in an attempt to introduce new small molecules that are potent and selective inhibitors identified as MDR, we screened 2000 small molecule compounds by the NCI diversity set library for compounds that can reverse MDR in drug lines, resistant cells. We identified two compounds, tetrandrine on 2000 13 and 2 4 2 May quinolinyl piperidinyl methanol as connections with the h Chsten activity t as pregnancy agents5ter MDR reversal. PDT can be used also as an in vivo model for assessing response of the tumor in patients before of extraction unencumbered, ben unambiguously Term systemic chemotherapy after the surgery. Most sharing plans are to anthracyclines or taxanes PST today, the s Rs based and assessed effectively in phase III trials. Nevertheless, despite the growing number of clinical studies, the PST, the optimal therapy has not been determined.
In 2000, our group is an individualized treatment of DVT in patients with locally advanced breast cancer, which is composed VX-770 of simple agents administered sequentially, according to the clinical efficacy. The aim of our study was the toxicity of t, effectiveness and outcome of this plan over a period of 7 years to evaluate. The patients and the study population and evaluation of pretreatment methods The study population included 102 patients with breast cancer participating in an hour Higher education, the University of t connected Medical Center in 2000, 2007, which were treated with our neoadjuvant regimen for reasons of preservation of the breast or inoperable disease at diagnosis. The scheme was also used to treat HER2-positive patients to be replaced until 2005, when he was replaced by a system with trastuzumab. Before treatment, the stage of the disease by k Rperliche examination, radiological assessment and metastatic work was to evaluate. Biopsy was not mandatory for lymph node staging of clearly pathological k Rperliche examination and imaging techniques, fine needle aspiration was diluted with knots Chtig made. The left ventricular Re ejection fraction was assessed by echocardiography or gated multi takeover.
The study was approved by our Institutional Review Board. All patients were treated with chemotherapy with doxorubicin 30 mg / m 2 / day for 3 consecutive days every 3 weeks. Their response was assessed every 6 three weeks. A complete clinical response, as no palpable tumor, and imaging was defined as a partial clinical response was a decline of 50% of the tumor size E in the k Defined rperlichen examination, imaging, or both. The toxicity was t classified according to the criteria of the National Cancer Institute Common Toxicity, version 3. These results were used to determine the number of treatment cycles. Patients with good clinical response was again U total of 4 courses. If the clinical completely Response to requests reference requests getting four G Lengths was achieved, the patient was referred for surgery. If a partial response was achieved after four G Lengths, was the treatment with paclitaxel 80 mg / m 2 is set.

Espectively. Neither patients mGluR operated au OUTSIDE the center was PCR, but the pathological response in these patients was as unm Possible to determine, because the surgical specimens were not available for examination and pathological response as unm Considered possible to determine the remaining 3 Patients who had taken a prim Ren tumor by biopsy. Pathological response was as unm Considered possible to determine in 6 patients underwent breast surgery in the presence of distant metastases. Therefore, the pathological response detectable detected in 318 patients. The operation was performed in 22 patients who had not carried out any evidence of metastatic disease w Found during the first staging.
The reason for not performing surgery in these patients was an inappropriate response and the persistence of surgery for locally advanced disease without the 7 patients, the detection of metastases at staging evaluation again after chemotherapy in two patients, refusal of surgery or radiotherapy Pr Conference final in 7 patients, poorly controlled psychiatric St tion in 2 patients and death in 4 patients. The death was thought to be the to progression of the disease in two F cases and was considered as m may on the other two F therapy cases in context. For at least the H Half of the patients the reason for the non-surgery was an inadequate response or progression to an m Resembled selection bias our right to refuse, was the Bev Lkerung evaluable pathologic response considered for all patients without metastases are distance, with the exception of five patients in whom evaluation of pathological response was not m possible, for technical reasons or relocation of a substantial portion of the tumor before surgery or therapeutic biopsy au outside the center. The prognostic significance of PCR has been studied only in patients in whom a pathological response was determined. RFS and OS were evaluated in all patients without distant metastases. Was determined using 318 patients with pathological reaction, PCR was observed in 61 patients.
Thus, in the evaluable Bev Lkerung, 340 patients, CRP was 18%. Since the profile of the sample inadequate forimmunohistochemical pr Surgery was tumor-Ph Genotype of the resected specimen in 16 F Cases identified. Ki67 was not evaluated in these patients. Tumor-Ph Genotype no longer in a patient, the surgical specimen was insufficient to determine PCR and immunohistochemical analysis for the advance. LN axillary dissection was not performed on a patient, and LN involvement could not be determined in 320 patients without distant metastases. The average number of examinees was 10 LN. LN metastasis was detected in 134 patients, and the number of LN 1 ranged up to 16 participants. Among patients with bilateral breast cancer, 3 had distant metastases at diagnosis and none of the four remaining patients were PCR. CRP was significantly h Be treated, under 55, patients with tumors overexpressing p53 HER 2, high expression of Ki67 and do not press the ER or PR forth in patients with DD regime. CRP dose of claim and the subgroup of patients with tumor-Ph Defined genotype is summarized in Table 3. PCR was observed in 6% of evaluable patients with ER / PR HER 2, 28% of patients with AS 2 and 43% of patients with TN Ph genotype. The proportion of p.