Moreover, the BOLD signal within the right substantia nigra
of midbrain, brainstem was more significantly (P0001) activated than its left counterpart in participants with left CSP, while no activation was observed in those with right CSP. The similar activation of the cerebellum was in participants with right CSP. The inferior parietal AICAR mouse lobule, inferior frontal gyrus and left insular cortex were significantly (P0001) activated in participants with CSP. These findings suggest a relationship between hemispheric dominance and CSP in the primary sensorimotor cortex responsible for rhythmic chewing movement. The brainstem and the cerebellum might also play important role in the regulation of CSP. Furthermore, the IFG, IPL and insular may contribute to higher cognitive information processing for participants with CSP.”
“Nanoscopy has now become a real procedure in fluorescence microscopy of living cells.
The STED/RESOLFT family of nanoscopy approaches has the best DMXAA prospects for delivering high speed imaging, but the history of STED includes a continuing struggle to reduce the deactivation power applied, along with difficulties in achieving simultaneous multicolor images. In this manuscript, we present a concept for a similar real-time nanoscopy, using a new class of bipartite probes that separate the luminescent and quenching functions into two coupled molecules. In particular, the STAQ (Superresolution via Transiently Activated Quencher) example we show herein employs the excited state absorbance (not ground state) of the partner to accept energy from and quench the luminescent dye. The result is that much
less deactivation power is needed for superresolved (approximate to 50 nm) imaging. Moreover, the TAQ partner excited by the donut beam is shown to quench several different visible dyes via the same mechanism, opening the door to easier multicolor imaging. We demonstrate three dyes sharing the same deactivation and show examples of superresolved multicolor images. We suggest STAQ will facilitate the growth of real-time nanoscopy by reducing confounding photodamage within living cells while expanding the nanoscopist’s palette. Microsc. Res. Tech. Quisinostat 78:343-355, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA”
“Advances in our understanding of terrestrial planet formation have come from a multidisciplinary approach. Studies of the ages and compositions of primitive meteorites with compositions similar to the Sun have helped to constrain the nature of the building blocks of planets. This information helps to guide numerical models for the three stages of planet formation from dust to planetesimals (similar to 10(6) y), followed by planetesimals to embryos (lunar to Mars-sized objects; few x 10(6) y), and finally embryos to planets (10(7)-10(8) y).